ChemicalBook > CAS DataBase List > Akebia saponin D

Akebia saponin D

Product Name: Akebia saponin D
CAS No.: 39524-08-8
Chemical Name: Akebia saponin D
Synonyms: Asperosap;AkebosideD;AsperosaponinⅥ;Asperosaponin Ⅵ;Asperosaponin VI;Akebia saponin D;Dipsacaceae saponin;Asperosaponin VI-RM;Akebia saponin D USP/EP/BP;Asperosaponin VI (Akeboside D)
CBNumber: CB61267734
Molecular Formula: C47H76O18
Formula Weight: 929.1
MOL File: 39524-08-8.mol

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Akebia saponin D Property

Melting point:: 234-235 °C
Boiling point:: 990.2±65.0 °C(Predicted)
Density: 1.43
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form: Solid
pka: 12.50±0.70(Predicted)
color: White to Pale Beige
biological source: (Dipsacus asper)
optical activity: [α]/D +13 to +18°, c =0.5 in methanol
Water Solubility: H2O: 3mg/mL, clear (warmed)

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Safety

Safety Statements: 24/25
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1822
Product name: Akebia saponin D
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $117
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1822
Product name: Akebia saponin D
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $477
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL83275
Product name: Asperosaponin VI
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $437
Updated: 2025/07/31

TCI Chemical

Product number: A3635
Product name: Asperosaponin VI
Packaging: 100MG
Price: $345
Updated: 2025/07/31

TRC

Product number: A788600
Product name: AsperosaponinVI
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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Akebia saponin D Chemical Properties,Usage,Production

Chemical Properties

Derived from the root of Dipsacus asperoides CY Cheng et T .M. Ai.

Uses

Asperosaponin VI is a steroidal extract with anti-inflammatory and antinociceptive activity. long term use has been seen to attenuate cardiac dysfunction.

Definition

ChEBI: Akebia saponin D is a triterpenoid saponin that is hederagenin attached to a alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage and a 6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 28 via an ester linkage. It is the active ingredient found in the traditional Chinese herb Radix Dipsaci. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite, an anti-inflammatory agent, a bone density conservation agent, a neuroprotective agent and an antilipemic drug. It is a triterpenoid saponin, a trisaccharide derivative, a pentacyclic triterpenoid and a carboxylic ester. It is functionally related to a hederagenin.

Biological Activity

Akebia saponin D (ASD) is a bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall th at is used as an anti-osteoporosis drug. Akebia saponin D exhibits therapeutic effects in number of disease models including cancer, Alzheimerμs disease, cardiovascular disease, and bone fractures. Akebia saponin D protects against nonalcoholic fatty liver disease (NAFLD) liver damage in mice model of NAFLD. ASD decreases hepatic steatosis and heptocyte apoptosis through autophagy modulation. Akebia saponin D prevents oleic acid induced lipid droplets accumulation and increases autophagic flux BRL cells.

in vivo

Asperosaponin VI (20 mg/kg; intravenous injection; 3 weeks) can accelerate wound healing and angiogenesis in a full-thickness cutaneous wound model of rats^[3].
Asperosaponin VI (40 mg/kg; intraperitoneal injection; 3 weeks) has antidepressant effects in mice with chronic mild stress^[4].

Animal Model:	Male 8-week-old C57BL/6 mice treated chronic mild stress (CMS)^[4]
Dosage:	40 mg/kg
Administration:	Intraperitoneal injection (i.p.); 3 weeks
Result:	Significantly improved depression-like behaviors in CMS-induced mice, as shown by increased sucrose preference, prolonged latency in the forced swimming test and feeding latency in the novelty-suppressed feeding test, and shortened immobility time in the tail suspension test and forced swimming test. Partially reversed CMS-induced weight loss. Induced hippocampal microglia to switch from a pro-inflammatory to a neuroprotective phenotype, and regulated the levels of pro-inflammatory and anti-inflammatory cytokines. Exerted anti-inflammatory and antidepressant effects through PPAR-γ pathway. Promoted microglia-neuron crosstalk and prevented CMS-induced synaptic dysfunction of hippocampal neurons.

IC 50

Caspase 3

Akebia saponin D Preparation Products And Raw materials

Raw materials

Preparation Products

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Akebia saponin D Suppliers

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View Lastest Price from Akebia saponin D manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Akebia saponin D 39524-08-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-29

Shanghai Standard Technology Co., Ltd.

Product: Akebia saponin D 39524-08-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-09-29

Career Henan Chemical Co

Product: Akebia saponin D 39524-08-8
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2018-08-10

39524-08-8, Akebia saponin DRelated Search:

Pennogenin 3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-xylopyranosyl-(1-4)-beta-D-glucopyranoside 4'-O-Acetyl-akebia saponin D Dipsanoside A 3-[[2-O-(α-L-Rhamnopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid Dipsanoside B oleanolic acid-3-O-β-D-glucopyranosyl (1→2)-α-L-arabinopyranoside Sylvestroside I dipsacoside B (3beta,25R)-14-Hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-xylopyranosyl-(1-4)]-beta-D-glucopyranoside TRIBULOSIDE Saponin

Akebia saponin D

Asperosaponin VI

Hederagenin 3-O-alpha-L-arabinopyranosyl-28-beta-D-glucopyranosyl(1→6)-beta-D-glucopyranoside

Akebia saponin D(Asperosaponin VI)

Dipsacaceae saponin

3'-Amino-2'-Hydroxy-1,1' biphenyl-3-cAsperosaponin VI

Asperosaponin VI, 98%, from Dipsacales

Asperosaponin Ⅵ

Asperosaponin VI (Akeboside D)

AkebosideD

Olean-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-23-hydroxy-, 6-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester, (3β,4α)-

Akebia saponin D USP/EP/BP

TIANFUCHEM--39524-08-8--High purity Akebia saponin D factory price

Asperosap

1-O-[(3b)-3-(a-L-Arabinopyranosyloxy)-23-hydroxy-28-oxoolean-12-en-28-yl]-6-O-D-glucopyranosyl-b-D-glucopyranose

(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl (4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate

Asperosaponin VI-RM

3’-Amino-2’-Hydroxy-1,1’ biphenyl-3-cAsperosaponin VI

Asperosaponin VI, 10 mM in DMSO

AsperosaponinⅥ

39524-08-8

C47H76O18

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract