l-Pimobendan

l-Pimobendan Property

Boiling point:

471.18°C (rough estimate)

Density 

1.2421 (rough estimate)

refractive index 

1.6620 (estimate)

pka

10.21±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

l-Pimobendan Chemical Properties,Usage,Production

Uses

(-)-Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-)-pimobedan from erythrocytes is significantly lower than that of (+)-pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-)-pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+)-isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-)-pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use.

Definition

ChEBI: Pimobendan is a pyridazinone and a member of benzimidazoles. It has a role as a cardiotonic drug, a vasodilator agent and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

References

[1] Plasma and red blood cell pharmacokinetics of pimobendan enantiomers in healthy Chinese