5H-Cyclopenta[c]pyridin-5-one,6,7-dihydro-(9CI)
- Product Name
- 5H-Cyclopenta[c]pyridin-5-one,6,7-dihydro-(9CI)
- CAS No.
- 350847-80-2
- Chemical Name
- 5H-Cyclopenta[c]pyridin-5-one,6,7-dihydro-(9CI)
- Synonyms
- 6,7-dihydro-5H-cyclopenta[c]pyridin-5-one;6,7-Dihydro-5H-[2]pyrindin-5-one;5H,6H,7H-cyclopenta[c]pyridin-5-one;6,7-dihydrocyclopenta[c]pyridin-5-one;6,7-dihydro-1H-cyclopenta[c]pyridin-5-one;6,7-Dihydro-5H-cyclopental[c]pyridin-5-one;6,7-Dihydro-5H-cyclopental[c]pyridine-5-one;5H-Cyclopenta[c]pyridin-5-one, 6,7-dihydro-;5H-Cyclopenta[c]pyridin-5-one,6,7-dihydro-(9CI)
- CBNumber
- CB61271740
- Molecular Formula
- C8H7NO
- Formula Weight
- 133.15
- MOL File
- 350847-80-2.mol
5H-Cyclopenta[c]pyridin-5-one,6,7-dihydro-(9CI) Property
- Boiling point:
- 267.4±9.0 °C(Predicted)
- Density
- 1.230±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- pka
- 3.56±0.20(Predicted)
- Appearance
- Brown to black Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D456045
- Product name
- 6,7-dihydro-5H-cyclopenta[c]pyridin-5-one
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 4302AB
- Product name
- 6,7-Dihydro-5H-cyclopenta[c]pyridin-5-one
- Packaging
- 250mg
- Price
- $317
- Updated
- 2021/12/16
- Product number
- 69R0625
- Product name
- 6,7-Dihydro-[2]pyrindin-5-one
- Purity
- 98%
- Packaging
- 50mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 69R0625
- Product name
- 6,7-Dihydro-[2]pyrindin-5-one
- Purity
- 98%
- Packaging
- 100mg
- Price
- $163
- Updated
- 2021/12/16
- Product number
- 69R0625
- Product name
- 6,7-Dihydro-[2]pyrindin-5-one
- Purity
- 98%
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
5H-Cyclopenta[c]pyridin-5-one,6,7-dihydro-(9CI) Chemical Properties,Usage,Production
Synthesis
19608-41-4
350847-80-2
General procedure for the synthesis of 6,7-dihydro-5H-cyclopentadieno[c]pyridin-5-one from methyl 3-(3-ethoxy-3-oxopropyl)isonicotinate: to a tetrahydrofuran (THF, 5.0 mL) solution of methyl 3-(3-ethoxy-3-oxopropyl)isonicotinate (300 mg, 1.26 mmol) was added potassium 2-methylpropan-2-ol ( 0.28 g, 2.52 mmol). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the solvent was evaporated to dryness. Concentrated hydrochloric acid (5 mL) was added to the residue and the reaction mixture was stirred at 100 °C for 2 hours. After continuing to stir at 100 °C for 16 h, saturated aqueous sodium bicarbonate (40 mL) and ethyl acetate (EtOAc, 50 mL) were added to the reaction vessel, and the resulting two-phase mixture was transferred to a partition funnel. The organic and aqueous layers were separated and the aqueous phase was extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting oil was purified by fast column chromatography using isocratic elution conditions of ethyl acetate (35%) and hexane (65%) to afford 6,7-dihydro-5H-cyclopenta[c]pyridin-5-one (0.03 g, 0.23 mmol) as a gray oil.
References
[1] Patent: WO2018/26371, 2018, A1. Location in patent: Paragraph 0132; 0134; 0283
5H-Cyclopenta[c]pyridin-5-one,6,7-dihydro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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