ChemicalBook > CAS DataBase List > 2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI)
2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI)
- Product Name
- 2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI)
- CAS No.
- 588674-64-0
- Chemical Name
- 2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI)
- Synonyms
- VUN74640;CCR6 antagonist 1;1,CCR6?antagonist?1;CCR6 antagonist 1, 10 mM in DMSO;3-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-2-carboxamide;2-Benzofurancarboxamide, 3-methyl-N-[4-(trifluoromethyl)phenyl]-;2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI)
- CBNumber
- CB61295784
- Molecular Formula
- C17H12F3NO2
- Formula Weight
- 319.28
- MOL File
- 588674-64-0.mol
More
Less
2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI) Property
- Boiling point:
- 345.9±42.0 °C(Predicted)
- Density
- 1.358±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (313.20 mM)
- form
- Solid
- pka
- 12.24±0.70(Predicted)
- color
- White to off-white
More
Less
2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI) Chemical Properties,Usage,Production
Uses
CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1].
in vivo
CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice[1].
?
CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice[1].
| Animal Model: | Murine model of colitis (5 mg/mouse TNBS-induced)[1] |
| Dosage: | 1 mg/kg |
| Administration: | Subcutaneous injection (s.c.), twice daily for 3 days. |
| Result: | Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs. |
| Animal Model: | Zymosan-induced peritonitis mice[1] |
| Dosage: | 1 mg/kg |
| Administration: | Subcutaneous injection (s.c.), twice, before and after zymosan treatment |
| Result: | Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage. |
IC 50
CCR6
References
[1] Maria Grazia Martina, et al. Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases. Eur J Med Chem. 2022 Aug 29;243:114703. DOI:10.1016/j.ejmech.2022.114703
2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI) Suppliers
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9119
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 020-82000279 18988941452
- Fax
- QQ：3283937693
- YN_research@163.com
- Country
- China
- ProdList
- 3011
- Advantage
- 58
- Tel
- 15092083467
- 18660263263@163.com
- Country
- China
- ProdList
- 2806
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 4798
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62220
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 0512-65118909 18100677375
- sales@szzxbio.com
- Country
- China
- ProdList
- 2993
- Advantage
- 58
- Tel
- 025-86755008 17751752005
- hszhang@bestfluorodrug.com
- Country
- China
- ProdList
- 2820
- Advantage
- 58