3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI)

Product Name: 3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI)
CAS No.: 163213-19-2
Chemical Name: 3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI)
Synonyms: tert-butyl 6-hydrazinylnicotinate;2-Methyl-2-propanyl 6-hydrazinonicotinate;6-Hydrazino-nicotinic acid tert-butyl ester;3-Pyridinecarboxylic acid, 6-hydrazinyl-, 1,1-dimethylethyl ester;3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI)
CBNumber: CB61301203
Molecular Formula: C10H15N3O2
Formula Weight: 209.24
MOL File: 163213-19-2.mol

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3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI) Property

Boiling point:: 317.0±52.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 9.03±0.70(Predicted)
Appearance: Light brown to brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B700678
Product name: tert-Butyl6-Hydrazinylnicotinate
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Ambeed

Product number: A214793
Product name: tert-Butyl6-hydrazinylnicotinate
Purity: 97%
Packaging: 5g
Price: $277
Updated: 2021/12/16

Chemenu

Product number: CM177948
Product name: tert-butyl6-hydrazinylnicotinate
Purity: 95%
Packaging: 5g
Price: $421
Updated: 2021/12/16

Crysdot

Product number: CD11242613
Product name: tert-Butyl6-hydrazinylnicotinate
Purity: 95%
Packaging: 5g
Price: $446
Updated: 2021/12/16

Chemcia Scientific

Product number: CC00-2814
Product name: 6-Hydrazino-nicotinicacidtert-butylester
Purity: ＞97%
Packaging: 5G
Price: $465
Updated: 2021/12/16

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3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI) Chemical Properties,Usage,Production

Synthesis

115309-57-4

163213-19-2

The general procedure for the synthesis of tert-butyl 6-hydrazinonicotinate from tert-butyl 6-chloronicotinate was as follows: first, 18.0 g (84.2 mmol) of tert-butyl 6-chloro-pyridine-3-carboxylate was dissolved in 85 mL of ethanol. Subsequently, 42.2 g (842.0 mmol) of hydrazine hydrate was added to the solution and the reaction mixture was stirred and reacted at 100 °C for 2 hours. Upon completion of the reaction, the mixture was concentrated to remove the solvent. The concentrated residue was dissolved in a solvent mixture of ethyl acetate and water for phase separation. The organic phase was washed sequentially with water and saturated sodium chloride solution each, and then dried with magnesium sulfate. The dried organic phase was concentrated again to obtain the crude product. The crude product was ground with petroleum ether, the solid formed was collected by filtration and dried under high vacuum to give 16.4 g (78% yield) of tert-butyl 6-hydrazinonicotinate. The product was analyzed by LC-MS (Method 1) showing Rt = 2.30 min; MS (ESIpos): m/z = 210 [M + H]+; 1H-NMR (400 MHz, DMSO-d6) data were as follows: δ= 8.49 (d, 1H), 8.30 (s, 1H), 7.82 (dd, 1H), 6.70 (d, 1H). 4.35 (s, 2H), 1.50 (s, 9H).

References

[1] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 442 - 445
[2] Patent: US2010/93803, 2010, A1. Location in patent: Page/Page column 21-22

3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI) Suppliers

China 35 Europe 1 India 1 United States 2 Global 39

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163213-19-2, 3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI)Related Search:

3-Pyridinecarboxylicacid,6-hydrazino-,1,1-dimethylethylester(9CI)

tert-butyl 6-hydrazinylnicotinate

2-Methyl-2-propanyl 6-hydrazinonicotinate

6-Hydrazino-nicotinic acid tert-butyl ester

3-Pyridinecarboxylic acid, 6-hydrazinyl-, 1,1-dimethylethyl ester

163213-19-2

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