ChemicalBook > CAS DataBase List > BM 212

BM 212

Product Name: BM 212
CAS No.: 146204-42-4
Chemical Name: BM 212
Synonyms: BM 212;BM 212;BM-212;1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine;BM-212,Inhibitor,Mycobacterium,BM 212,BM212,MmpL3,Bacterial,inhibit,tuberculosis;Piperazine, 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-
CBNumber: CB61304163
Molecular Formula: C23H25Cl2N3
Formula Weight: 414.37
MOL File: 146204-42-4.mol

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BM 212 Property

Boiling point:: 528.3±50.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:0.75(Max Conc. mg/mL);1.81(Max Conc. mM)
Ethanol:3.03(Max Conc. mg/mL);7.31(Max Conc. mM)
form: A crystalline solid
pka: 7.60±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22986
Product name: BM212
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22986
Product name: BM212
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 22986
Product name: BM212
Purity: ≥98%
Packaging: 10mg
Price: $261
Updated: 2024/03/01

AK Scientific

Product number: 3177CC
Product name: Piperazine,1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methyl-
Packaging: 10mg
Price: $387
Updated: 2021/12/16

ChemScene

Product number: CS-5953
Product name: BM212
Purity: 99.87%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

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BM 212 Chemical Properties,Usage,Production

Uses

BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 μM[1][2].

References

[1] Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. DOI:10.1128/AAC.42.11.3035
[2] Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) DOI:10.1371/journal.pone.0056980
[3] Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. DOI:10.1039/c9nh00736a
[4] Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. DOI:10.1128/AAC.42.11.3035

BM 212 Preparation Products And Raw materials

Raw materials

Preparation Products

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146204-42-4, BM 212Related Search:

BM 212

BM 212;BM-212

1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine

Piperazine, 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-

BM-212,Inhibitor,Mycobacterium,BM 212,BM212,MmpL3,Bacterial,inhibit,tuberculosis

146204-42-4

C23H25Cl2N3