17-(3-pyridyl)androsta-5,16-dien-3-one
- Product Name
- 17-(3-pyridyl)androsta-5,16-dien-3-one
- CAS No.
- 154229-21-7
- Chemical Name
- 17-(3-pyridyl)androsta-5,16-dien-3-one
- Synonyms
- CB-7627;D4-abiraterone;Δ4-Abiraterone;Abiraterone (D4A);3-Keto Abiraterone;Delta 4-Abiraterone;Abiraterone Impurity 59;Abiraterone Impurity 41;D4-abiraterone (CB-7627);Abiraterone D4A metabolite
- CBNumber
- CB61312708
- Molecular Formula
- C24H29NO
- Formula Weight
- 347.49
- MOL File
- 154229-21-7.mol
17-(3-pyridyl)androsta-5,16-dien-3-one Property
- Boiling point:
- 504.6±50.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 10 mg/ml
- form
- powder
- pka
- 5.32±0.12(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1963
- Product name
- Abiraterone D4A metabolite
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $121
- Updated
- 2025/07/31
- Product number
- SML1963
- Product name
- Abiraterone D4A metabolite
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $489
- Updated
- 2025/07/31
- Product number
- 27594
- Product name
- Δ4-Abiraterone
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 27594
- Product name
- Δ4-Abiraterone
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- 27594
- Product name
- Δ4-Abiraterone
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
17-(3-pyridyl)androsta-5,16-dien-3-one Chemical Properties,Usage,Production
Uses
17-(3-Pyridinyl)-androsta-4,16-dien-3-one is a possible steroidal inhibitor of human cytochrome P 45017α-hydroxylase-C17,20-lyase.
Biological Activity
D4A (Δ4-Abiraterone; 3-Pyridinyl)-androsta-4,16-dien-3-one) is an abiraterone metabolite found to be more active than abiraterone. Abiraterone is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme th at catalyzes two key serial reactions (17 alpha hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition can stop the production of androgens in both places. It is approved for the treatment of metastatic castration-resistant prostate cancer. D4A blocks not only CYP17A1, but also blocks two other enzymes, 3?-hydroxysteroid dehydrogenase (3?HSD) and steroid-5?-reductase (SRD5A), which are involved in producing the androgen 5?-dihydrotestosterone (DHT), while also blocking the androgen receptor.
in vivo
D4-abiraterone is tenfold more potent than Abiraterone in blocking conversion from dehydroepiandrosterone (DHEA) by 3β-hydroxysteroid dehydrogenase (3βHSD) to D4-androstenedione (AD) in LNCaP and VCaP xenografts. 0.1 μM D4-abiraterone is equivalent to 1 μM Abiraterone for blocking AD accumulation at 48 h in both LNCaP and VCaP xenografts. Progression is significantly delayed in the D4-abiraterone group compare with the Abiraterone acetate group[1].
IC 50
CYP17
17-(3-pyridyl)androsta-5,16-dien-3-one Preparation Products And Raw materials
Raw materials
Preparation Products
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