ChemicalBook > CAS DataBase List > Ro 46-8443

Ro 46-8443

Product Name
Ro 46-8443
CAS No.
175556-12-4
Chemical Name
Ro 46-8443
Synonyms
Ro 46-8443;CID 9916886;RO46-8443, CID 5312146;4-TERT-BUTYL-N-[6-[(2R)-2,3-DIHYDROXYPROPOXY]-5-(2-METHOXYPHENOXY)-2-(4-METHOXYPHENYL)PYRIMIDIN-4-YL]BENZENESULFONAMIDE;(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide;Inhibitor,RO 468443,Ro 46-8443,selective,ETB,normotensive,RO 46 8443,inhibit,Endothelin Receptor,hypertensive rats,non-peptide;(R)-N-[6-(2,3-Dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)benzenesulfonamide;Benzenesulfonamide, N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)-
CBNumber
CB61325247
Molecular Formula
C31H35N3O8S
Formula Weight
609.69
MOL File
175556-12-4.mol
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Ro 46-8443 Property

storage temp. 
2-8°C
solubility 
DMSO : 250 mg/mL (410.04 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed
Product number
A1167274
Product name
(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
Purity
98%
Packaging
5mg
Price
$100
Updated
2021/12/16
Ambeed
Product number
A1167274
Product name
(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
Purity
98%
Packaging
10mg
Price
$171
Updated
2021/12/16
CSNpharm
Product number
CSN24483
Product name
Ro46-8443
Packaging
10mg
Price
$214
Updated
2021/12/16
Ambeed
Product number
A1167274
Product name
(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
Purity
98%
Packaging
25mg
Price
$228
Updated
2021/12/16
Ambeed
Product number
A1167274
Product name
(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
Purity
98%
Packaging
50mg
Price
$296
Updated
2021/12/16
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Ro 46-8443 Chemical Properties,Usage,Production

Uses

Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM)[1][2].

IC 50

ETB: 34-69 nM (IC50); ETA: 6800 nM (IC50)

References

[1] Breu V, et al. In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ETB receptor. FEBS Lett. 1996;383(1-2):37-41. DOI:10.1016/0014-5793(96)00213-x
[2] Clozel M, et al. The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443. FEBS Lett. 1996;383(1-2):42-45. DOI:10.1016/0014-5793(96)00212-8

Ro 46-8443 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 46-8443 Suppliers

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Shanghai Boyle Chemical Co., Ltd.
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Nanjing Norris-Pharm Technology Co., Ltd
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+86 (21) 2024-2659
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Shanghai Biopharmaleader Co., Ltd.
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Career Henan Chemica Co
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175556-12-4, Ro 46-8443Related Search:


  • Ro 46-8443
  • (R)-N-[6-(2,3-Dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)benzenesulfonamide
  • 4-TERT-BUTYL-N-[6-[(2R)-2,3-DIHYDROXYPROPOXY]-5-(2-METHOXYPHENOXY)-2-(4-METHOXYPHENYL)PYRIMIDIN-4-YL]BENZENESULFONAMIDE
  • RO46-8443, CID 5312146
  • Benzenesulfonamide, N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)-
  • (R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
  • Inhibitor,RO 468443,Ro 46-8443,selective,ETB,normotensive,RO 46 8443,inhibit,Endothelin Receptor,hypertensive rats,non-peptide
  • CID 9916886
  • 175556-12-4
  • C31H35N3O8S