amidepsine A

Product Name: amidepsine A
CAS No.: 169181-28-6
Chemical Name: amidepsine A
Synonyms: FO 2942A;Amidepsin A;amidepsine A;2,4-Dimethoxy-6-methyl-benzoic acid 4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenyl ester;Benzoic acid, 2,4-dimethoxy-6-methyl-, 4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenyl ester
CBNumber: CB61331141
Molecular Formula: C29H29NO11
Formula Weight: 567.54
MOL File: 169181-28-6.mol

More

Less

amidepsine A Property

Boiling point:: 773.3±60.0 °C(Predicted)
Density: 1.356±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in methanol
form: Pale white to pale yellow powder.
pka: 3.53±0.10(Predicted)
color: Pale white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 17774
Product name: Amidepsine A
Purity: ≥95%
Packaging: 1mg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 17774
Product name: Amidepsine A
Purity: ≥95%
Packaging: 2.5mg
Price: $533
Updated: 2024/03/01

TRC

Product number: A576680
Product name: AmidepsineA
Packaging: 2.5mg
Price: $430
Updated: 2021/12/16

Usbiological

Product number: 207043
Product name: Amidepsine A
Packaging: 1mg
Price: $443
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CN2-0109-M001
Product name: AmidepsineA
Purity: ≥95%(HPLC)
Packaging: 1mg
Price: $230
Updated: 2021/12/16

More

Less

amidepsine A Chemical Properties,Usage,Production

Uses

Amidepsine A is a fungal metabolite, isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity.

Biological Activity

amidepsine a is a fungal metabolite isolated from the culture broth of humicola sp fo-2942. amidepsine a is an inhibitor of dylglycerol acyltransferase (dgat).dylglycerol acyltransferase (dgat) has been involved in catalyzing the formation of triglycerides from diacylglycerol and acyl-coa. the reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. there are two isozymes of dgat have been identified: dgat1 and dgat2. dgat-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance [1]. dgat2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities [2].fo-2942 inhibited dgat activity with an ic50 of 10.2 μm in rat liver microsomes. fo-2942 inhibited triacylglycerol formation in raji cells with the ic50 value of 15.5 μm [1].

storage

+4°C

References

[1] tomoda h, tabata n, ito m, et al. amidepsines, inhibitors of diacylglycerol acyltransferase produced by humicola sp. fo-2942[j]. the journal of antibiotics, 1995, 48(9): 942-947.
[2] smith s j, cases s, jensen d r, et al. obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking dgat[j]. nature genetics, 2000, 25(1): 87-90.
[3] stone s j, myers h m, watkins s m, et al. lipopenia and skin barrier abnormalities in dgat2-deficient mice[j]. journal of biological chemistry, 2004, 279(12): 11767-11776.

amidepsine A Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

amidepsine A Suppliers

China 30 United Kingdom 1 United States 9 USA 1 Global 41

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3656
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-0571-89903882 15990081639
Email: sunshixuan@huidabiotech.com
Country: China
ProdList: 3705
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6813
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 70071
Advantage: 58

169181-28-6, amidepsine ARelated Search:

amidepsine A

2,4-Dimethoxy-6-methyl-benzoic acid 4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenyl ester

FO 2942A

Benzoic acid, 2,4-dimethoxy-6-methyl-, 4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenyl ester

Amidepsin A

169181-28-6

C29H29NO11