3-CHLORO-L-ALANINE HYDROCHLORIDE
- Product Name
- 3-CHLORO-L-ALANINE HYDROCHLORIDE
- CAS No.
- 51887-89-9
- Chemical Name
- 3-CHLORO-L-ALANINE HYDROCHLORIDE
- Synonyms
- Chloro L;H-ALA(3-CL)-OH HCL;H-b-Chloro-Ala-OH·HCl;3-Chloro-L-alanineHCl;b-Chloro-L-Ala-OH·HCl;BETA-CHLORO-ALANINE HCL;H-BETA-CHLORO-ALA-OH HCL;B-CHLORO-L-ALANINE HYDROCHLORIDE;β-chloro-l-alanine hydrochloride;3-CHLORO-L-ALANINE HYDROCHLORIDE
- CBNumber
- CB6133203
- Molecular Formula
- C3H7Cl2NO2
- Formula Weight
- 160
- MOL File
- 51887-89-9.mol
3-CHLORO-L-ALANINE HYDROCHLORIDE Property
- Melting point:
- 205 °C (dec.)(lit.)
- storage temp.
- -20°C
- form
- powder to crystal
- color
- White to Almost white
- biological source
- synthetic
- Water Solubility
- water: 50mg/mL, clear, colorless
- InChIKey
- IENJPSDBNBGIEL-DKWTVANSSA-N
- CAS DataBase Reference
- 51887-89-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C9033
- Product name
- β-Chloro-L-alanine hydrochloride
- Purity
- Alanine aminotransferase inhibitor
- Packaging
- 250mg
- Price
- $303
- Updated
- 2025/07/31
- Product number
- C9033
- Product name
- β-Chloro-L-alanine hydrochloride
- Purity
- Alanine aminotransferase inhibitor
- Packaging
- 5g
- Price
- $1323
- Updated
- 2025/07/31
- Product number
- C1612
- Product name
- 3-Chloro-L-alanine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- C1612
- Product name
- 3-Chloro-L-alanine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $811
- Updated
- 2021/12/16
- Product number
- A617713
- Product name
- (R)-2-Amino-3-chloropropanoicAcidHydrochloride
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
3-CHLORO-L-ALANINE HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
β-Chloro-L-alanine hydrochloride has been used:
- as a substrate for screening tyrosine phenol lyase steady state kinetics
- in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells
- as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system
Biochem/physiol Actions
β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.
Synthesis
16428-75-4
51887-89-9
General procedure for the synthesis of 3-chloro-L-alanine hydrochloride from L-serine hydrochloride: L-serine hydrochloride (100 g, 0.7067 mol) was suspended in 500 ml of tetrahydrofuran, and the temperature of the reaction was controlled to be lower than 50 °C, and thionyl chloride (101 g, 0.8480 mol) was added dropwise slowly. After the dropwise addition, the temperature was gradually increased to 50 °C and the reaction was stirred continuously for 6 hours. After confirming the complete consumption of raw materials by thin layer chromatography (TLC) monitoring, the reaction system was cooled to 20~25°C. The reaction was quenched by the slow addition of 50 ml of water and subsequently concentrated to dryness under reduced pressure. To the residue, 200 ml of acetone was added, cooled to 25 °C for crystallization, and the crystals were collected by filtration and dried to afford 100 g of off-white solid 3-chloro-L-alanine hydrochloride in 88.4% yield.
References
[1] Patent: CN105294528, 2016, A. Location in patent: Paragraph 0023; 0024
[2] Patent: US6372941, 2002, B1. Location in patent: Example 9
3-CHLORO-L-ALANINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLORO-L-ALANINE HYDROCHLORIDE manufacturers
- Product
- 3-CHLORO-L-ALANINE HYDROCHLORIDE 51887-89-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31