N-desferriferrichrome
- Product Name
- N-desferriferrichrome
- CAS No.
- 34787-28-5
- Chemical Name
- N-desferriferrichrome
- Synonyms
- deferrichrome;DesferrichroMe;Deferriferrichrome;Ferrichrome Iron-free;N-desferriferrichrome;Ferrichrome Iron-free from Ustilago sphaerogena;Cyclo(glycylglycylglycyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl)
- CBNumber
- CB61342570
- Molecular Formula
- C27H45N9O12
- Formula Weight
- 687.7
- MOL File
- 34787-28-5.mol
N-desferriferrichrome Property
- Melting point:
- 197-203°C
- storage temp.
- 2-8°C
- solubility
- DMSO, Methanol
- form
- Solid
- color
- White to Off-White
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- F8014
- Product name
- Ferrichrome Iron-free from Ustilago sphaerogena
- Packaging
- 1mg
- Price
- $78.9
- Updated
- 2025/07/31
- Product number
- F8014
- Product name
- Ferrichrome Iron-free from Ustilago sphaerogena
- Packaging
- 5mg
- Price
- $272
- Updated
- 2025/07/31
- Product number
- 19528
- Product name
- Ferrichrome (iron-free)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $46
- Updated
- 2024/03/01
- Product number
- 19528
- Product name
- Ferrichrome (iron-free)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $79
- Updated
- 2024/03/01
- Product number
- 19528
- Product name
- Ferrichrome (iron-free)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $322
- Updated
- 2024/03/01
N-desferriferrichrome Chemical Properties,Usage,Production
Description
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus. Ferrichrome (0.8 μM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor. It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.
Uses
Growth-promoting iron chelator. Ferrichrome iron-free from Ustilago sphaerogena.
Definition
ChEBI: A homodetic cyclic peptide composed from two units of three glycyl and three N5-acetyl-N5-hydroxy-L-ornithyl residues.
Biochem/physiol Actions
Growth-promoting iron chelator
References
[1] EMERY T. Role of ferrichrome as a ferric ionophore in Ustilago sphaerogena[J]. Biochemistry Biochemistry, 1971, 10 8: 1483-1488. DOI: 10.1021/bi00784a033
[2] I AUTENRIETH J H K Hantke. Immunosuppression of the host and delivery of iron to the pathogen: a possible dual role of siderophores in the pathogenesis of microbial infections?[J]. Medical Microbiology and Immunology, 1991, 180 3: 135-141. DOI: 10.1007/bf00206117
[3] ISTVáN PóCSI. Fungal siderophores function as protective agents of LDL oxidation and are promising anti-atherosclerotic metabolites in functional food[J]. Molecular Nutrition & Food Research, 2008, 52 12: 1434-1447. DOI: 10.1002/mnfr.200700467
[4] MéLISSA HANNAUER. The ferrichrome uptake pathway in Pseudomonas aeruginosa involves an iron release mechanism with acylation of the siderophore and recycling of the modified desferrichrome.[J]. Journal of Bacteriology, 2010: 1212-1220. DOI: 10.1128/jb.01539-09
[5] TATSUYA FUNAHASHI. Identification and characterization of genes required for utilization of desferri-ferrichrome and aerobactin in Vibrio parahaemolyticus.[J]. Biological & pharmaceutical bulletin, 2009, 32 3: 359-365. DOI: 10.1248/bpb.32.359
N-desferriferrichrome Preparation Products And Raw materials
Raw materials
Preparation Products
N-desferriferrichrome Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71