flazin

Product Name: flazin
CAS No.: 100041-05-2
Chemical Name: flazin
Synonyms: flazin;Flazine;1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylicaci;1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid;9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-[5-(hydroxymethyl)-2-furanyl]-
CBNumber: CB61345122
Molecular Formula: C17H12N2O4
Formula Weight: 308.29
MOL File: 100041-05-2.mol

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flazin Property

Melting point:: 218-220 °C (decomp)
Boiling point:: 657.1±55.0 °C(Predicted)
Density: 1.513±0.06 g/cm3(Predicted)
pka: 1.30±0.30(Predicted)
InChI: InChI=1S/C17H12N2O4/c20-8-9-5-6-14(23-9)16-15-11(7-13(19-16)17(21)22)10-3-1-2-4-12(10)18-15/h1-7,18,20H,8H2,(H,21,22)
InChIKey: USBWYUYKHHILLZ-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC=C2)C2C=C(C(O)=O)N=C(C3=CC=C(CO)O3)C1=2

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Hazard and Precautionary Statements (GHS)

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flazin Chemical Properties,Usage,Production

Uses

Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor[1][2][3].

Definition

ChEBI: A natural product found in Cordyceps sinensis.

References

[1] Seong SH, et al. Discovery of Flazin, an Alkaloid Isolated from Cherry Tomato Juice, As a Novel Non-Enzymatic Protein Glycation Inhibitor viain Vitro and in Silico Studies. J Agric Food Chem. 2021 Mar 31;69(12):3647-3657. DOI:10.1021/acs.jafc.0c07486
[2] Wu X, et al. Flazin as a Lipid Droplet Regulator against Lipid Disorders. Nutrients. 2022 Apr 3;14(7):1501. DOI:10.3390/nu14071501
[3] Li H, et al. Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor. J Agric Food Chem. 2016 Jun 15;64(23):4725-34. DOI:10.1021/acs.jafc.6b01094

flazin Preparation Products And Raw materials

Raw materials

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flazin Suppliers

China 29 United States 4 USA 1 Global 34

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100041-05-2, flazinRelated Search:

flazin

1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid

Flazine

9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-[5-(hydroxymethyl)-2-furanyl]-

1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylicaci

100041-05-2