Eseroline
- Product Name
- Eseroline
- CAS No.
- 469-22-7
- Chemical Name
- Eseroline
- Synonyms
- eseroline;(-)-Eseroline DISCONTINUED. Offer only E889163;(3aS)-1,2,3,3a,8,8a-Hexahydro-1,3aα,8α-trimethylpyrrolo[2,3-b]indol-5-ol;(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol;Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS,8aR)-
- CBNumber
- CB61353338
- Molecular Formula
- C13H18N2O
- Formula Weight
- 218.29
- MOL File
- 469-22-7.mol
Eseroline Property
- Melting point:
- 128 °C
- Boiling point:
- 366.3±42.0 °C(Predicted)
- Density
- 1.160±0.06 g/cm3(Predicted)
- pka
- 10.17±0.40(Predicted)
- InChI
- InChI=1S/C13H18N2O/c1-13-6-7-14(2)12(13)15(3)11-5-4-9(16)8-10(11)13/h4-5,8,12,16H,6-7H2,1-3H3/t12-,13+/m1/s1
- InChIKey
- HKGWQUVGHPDEBZ-OLZOCXBDSA-N
- SMILES
- N1(C)C2=C(C=C(O)C=C2)[C@]2(C)CCN(C)[C@]12[H]
N-Bromosuccinimide Price
- Product number
- API0015244
- Product name
- ESEROLINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $144.9
- Updated
- 2021/12/16
Eseroline Chemical Properties,Usage,Production
Description
Eseroline is a drug which acts as an opioid agonist. It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible, and it produces fairly potent analgesic effects mediated through the μ-opioid receptor.
Chemical Properties
Physostigmine crystals or solutions, when heated, exposed to light and air, or in the presence of traces of metal, readily turn red, are more unstable to bases, and are readily hydrolyzed to eserobine, which are capable of being oxidized to red physostigmine salicylate, depriving the product of its therapeutic efficacy.
Occurrence
Eseroline, although derived from physostigmine by hydrolysis of N-methylcarbamoil group, is also structurally related to morphine.
Uses
(-)-Eseroline is a metabolite of physostigmine, displaying both anti-acetylcholinesterase and opiate agonist activities.
Definition
ChEBI: Eseroline is a pyrroloindole that is 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole substituted by methyl groups at positions 1, 3a and 8 and a hydroxy group at position 5. It is a metabolite of physostigmine and causes neuronal cell death by a mechanism involving loss of cell ATP. It has a role as an opioid analgesic and a human xenobiotic metabolite. It is a member of phenols and a pyrroloindole.
References
[1] RENZI G, BARTOLINI A, GALLI A, et al. The structure and action of eseroline: A new antinociceptive drug[J]. Inorganica Chimica Acta, 1980, 40. DOI:10.1016/S0020-1693(00)92145-5.
[2] SOMANIS M KrishnaG KuttyR K. Eseroline, a metabolite of physostigmine, induces neuronal cell death.[J]. Toxicology and applied pharmacology, 1990. DOI:10.1016/0041-008x(90)90102-z.
[3] BARTOLINI A, RENZI G, GALLI A, et al. Eseroline: A new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents[J]. Neuroscience Letters, 1981, 25: 179-183. DOI:10.1016/0304-3940(81)90328-1.
Eseroline Preparation Products And Raw materials
Raw materials
Preparation Products
Eseroline Suppliers
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- 021-52277372 13564545227
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- Country
- China
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- 029-81310890 13571859809
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View Lastest Price from Eseroline manufacturers
- Product
- Eseroline 469-22-7
- Price
- US $0.00/kg
- Min. Order
- 0.05kg
- Purity
- 99%
- Supply Ability
- 50kgs
- Release date
- 2024-05-13
- Product
- Eseroline 469-22-7
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000 tons
- Release date
- 2023-05-23
- Product
- Eseroline 469-22-7
- Price
- US $12.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 ton
- Release date
- 2021-02-07