Eseroline

Product Name: Eseroline
CAS No.: 469-22-7
Chemical Name: Eseroline
Synonyms: eseroline;(-)-Eseroline DISCONTINUED. Offer only E889163;(3aS)-1,2,3,3a,8,8a-Hexahydro-1,3aα,8α-trimethylpyrrolo[2,3-b]indol-5-ol;(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol;Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS,8aR)-
CBNumber: CB61353338
Molecular Formula: C13H18N2O
Formula Weight: 218.29
MOL File: 469-22-7.mol

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Eseroline Property

Melting point:: 128 °C
Boiling point:: 366.3±42.0 °C(Predicted)
Density: 1.160±0.06 g/cm3(Predicted)
pka: 10.17±0.40(Predicted)
InChI: InChI=1S/C13H18N2O/c1-13-6-7-14(2)12(13)15(3)11-5-4-9(16)8-10(11)13/h4-5,8,12,16H,6-7H2,1-3H3/t12-,13+/m1/s1
InChIKey: HKGWQUVGHPDEBZ-OLZOCXBDSA-N
SMILES: N1(C)C2=C(C=C(O)C=C2)[C@]2(C)CCN(C)[C@]12[H]

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0015244
Product name: ESEROLINE
Purity: 95.00%
Packaging: 10MG
Price: $144.9
Updated: 2021/12/16

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Eseroline Chemical Properties,Usage,Production

Description

Eseroline is a drug which acts as an opioid agonist. It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible, and it produces fairly potent analgesic effects mediated through the μ-opioid receptor.

Chemical Properties

Physostigmine crystals or solutions, when heated, exposed to light and air, or in the presence of traces of metal, readily turn red, are more unstable to bases, and are readily hydrolyzed to eserobine, which are capable of being oxidized to red physostigmine salicylate, depriving the product of its therapeutic efficacy.

Occurrence

Eseroline, although derived from physostigmine by hydrolysis of N-methylcarbamoil group, is also structurally related to morphine.

Uses

(-)-Eseroline is a metabolite of physostigmine, displaying both anti-acetylcholinesterase and opiate agonist activities.

Definition

ChEBI: Eseroline is a pyrroloindole that is 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole substituted by methyl groups at positions 1, 3a and 8 and a hydroxy group at position 5. It is a metabolite of physostigmine and causes neuronal cell death by a mechanism involving loss of cell ATP. It has a role as an opioid analgesic and a human xenobiotic metabolite. It is a member of phenols and a pyrroloindole.

References

[1] RENZI G, BARTOLINI A, GALLI A, et al. The structure and action of eseroline: A new antinociceptive drug[J]. Inorganica Chimica Acta, 1980, 40. DOI:10.1016/S0020-1693(00)92145-5.
[2] SOMANIS M KrishnaG KuttyR K. Eseroline, a metabolite of physostigmine, induces neuronal cell death.[J]. Toxicology and applied pharmacology, 1990. DOI:10.1016/0041-008x(90)90102-z.
[3] BARTOLINI A, RENZI G, GALLI A, et al. Eseroline: A new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents[J]. Neuroscience Letters, 1981, 25: 179-183. DOI:10.1016/0304-3940(81)90328-1.

Eseroline Preparation Products And Raw materials

Raw materials

Preparation Products

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Eseroline Suppliers

China 12 Global 12

Shanghai Eyougene biotechnology development co.LTD

Tel: 021-52277372 13564545227
Email: dom.sales@eyougene.com
Country: China
ProdList: 245
Advantage: 58

Shanghai Famo Bio-chemical Technology Company Ltd.

Tel: 021-36680027 15821745250
Email: fengqiang@famobiotech.com
Country: China
ProdList: 539
Advantage: 56

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-81138252 +86-18789408387
Fax: 029-88380327
Email: 1057@dideu.com
Country: China
ProdList: 3958
Advantage: 58

Neostar United (Changzhou) Industrial Co., Ltd.

Tel: +86-0519-85551759 +8613506123987
Fax: +0086-519-85557389
Email: marketing1@neostarunited.com
Country: China
ProdList: 8838
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81145920 13259709322
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 10007
Advantage: 58

Shanghai Leiming Medical Technology Co., LTD

Tel: 13761371720
Email: zhangleitao111@sina.com
Country: China
ProdList: 475
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Nantong Zhonghe Chemical New Materials Co., Ltd

Tel: 13003551299 13003551299
Email: 2369399482@qq.com
Country: China
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SUZHOU SENFEIDA CHEMICAL CO.,LTD

Tel: +86-0512-83500002 +8615195660023
Email: sales@senfeida.com
Country: China
ProdList: 23046
Advantage: 58

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Tel: +8618291886785
Email: olivia.wang@pushanshiye.com
Country: China
ProdList: 164
Advantage: 58

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View Lastest Price from Eseroline manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: Eseroline 469-22-7
Price: US $0.00/kg
Min. Order: 0.05kg
Purity: 99%
Supply Ability: 50kgs
Release date: 2024-05-13

Henan Bao Enluo International TradeCo.，LTD

Product: Eseroline 469-22-7
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000 tons
Release date: 2023-05-23

Shaanxi Dideu Medichem Co. Ltd

Product: Eseroline 469-22-7
Price: US $12.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 ton
Release date: 2021-02-07

469-22-7, EserolineRelated Search:

PILOCARPINE (-)-Huperzine A Acetylcholine

eseroline

(3aS)-1,2,3,3a,8,8a-Hexahydro-1,3aα,8α-trimethylpyrrolo[2,3-b]indol-5-ol

(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol

Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS,8aR)-

(-)-Eseroline DISCONTINUED. Offer only E889163

469-22-7