NF 279

Product Name: NF 279
CAS No.: 202983-32-2
Chemical Name: NF 279
Synonyms: NF 279;CS-319;NF279 - CAS 202983-32-2 - Calbiochem;8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid;8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid sodium salt;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt;8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt
CBNumber: CB6135641
Molecular Formula: C49H37N6NaO23S6
Formula Weight: 1293.2
MOL File: 202983-32-2.mol

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NF 279 Property

storage temp.: Desiccate at -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: White solid
Water Solubility: Soluble to 25 mM in water
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 480418
Product name: NF279 - CAS 202983-32-2 - Calbiochem<br />A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC /KB ~ 1 μM in smooth muscle).
Packaging: 5mg
Price: $251
Updated: 2024/03/01

Tocris

Product number: 1199
Product name: NF279
Purity: ≥95%(HPLC)
Packaging: 50
Price: $887
Updated: 2021/12/16

Tocris

Product number: 1199
Product name: NF279
Purity: ≥95%(HPLC)
Packaging: 10
Price: $212
Updated: 2021/12/16

TRC

Product number: N391680
Product name: NF279
Packaging: 250mg
Price: $2065
Updated: 2021/12/16

Usbiological

Product number: 255973
Product name: NF 279
Packaging: 10mg
Price: $466
Updated: 2021/12/16

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NF 279 Chemical Properties,Usage,Production

Uses

NF 279 is a potent and selective P2X1 antagonist.

General Description

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/K_B ~1 μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α_1A adrenoceptors, adenosine A₁ and A_2B receptors, histamine H₁, muscarinic M₃ and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X₁ >P2X₂ >P2X₃ >P2X₄ (IC₅₀ = 19 nM, 770 nM, 1.62 μM and >300 μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X₁ > human P2X₁ ? rat P2X₂ > rat P2X₃ ~human P2X₇ ? human P2X₄. Not degraded by ecto-nucleotidases.

Biological Activity

A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

NF 279 Preparation Products And Raw materials

Raw materials

Preparation Products

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NF 279 Suppliers

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202983-32-2, NF 279Related Search:

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NF 279

8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA

8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT

NF279 - CAS 202983-32-2 - Calbiochem

CS-319

8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex

8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt

8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid

8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid sodium salt

8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt

202983-32-2

C49H30N4Na6O21S6

C49H30N6O23S66Na

C49H30N6Na6O23S6

Purinergics P2 receptor