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OPC 21268

Product Name
OPC 21268
CAS No.
131631-89-5
Chemical Name
OPC 21268
Synonyms
CS-2724;Fuscoside;OPC 21268;OPC-21268 hydrate;OPC 21268;OPC-21268;OPC21268;Inhibitor,Vasopressin Receptor,OPC21268,Fuscoside,OPC-21268,inhibit;1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one;1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate;N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide;N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]acetamide
CBNumber
CB61356814
Molecular Formula
C26H31N3O4
Formula Weight
449.54
MOL File
131631-89-5.mol
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OPC 21268 Property

Boiling point:
772.5±60.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
pka
16.17±0.46(Predicted)
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O1016
Product name
OPC-21268 hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$814
Updated
2024/03/01
Sigma-Aldrich
Product number
O1016
Product name
OPC-21268 hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$267
Updated
2023/01/07
Cayman Chemical
Product number
27226
Product name
OPC 21268
Packaging
10mg
Price
$275
Updated
2024/03/01
Cayman Chemical
Product number
27226
Product name
OPC 21268
Packaging
25mg
Price
$606
Updated
2024/03/01
Cayman Chemical
Product number
27226
Product name
OPC 21268
Packaging
5mg
Price
$153
Updated
2024/03/01
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OPC 21268 Chemical Properties,Usage,Production

Description

OPC 21268 is a nonpeptide antagonist of vasopressin V1 receptors (IC50 = 0.4 μM in rat liver membranes). It is selective for V1 over V2 receptors (IC50 = >100 μM in kidney membranes). It is also selective for rat over human V1 receptors (Kis = 25 and 8,800 nM, respectively), which can be partially attributed to the alanine residue at position 337 of the rat sequence, instead of a glycine residue in the human sequence, with differences at positions 224, 310, and 324 also contributing. OPC 21268 (0.03-1 mg/kg, i.v.) inhibits pressor responses induced by arginine vasopressin (argipressin; ) in pithed rats and arginine vasopressin-induced vasoconstriction in conscious rats (ID50 = 2 mg/kg). It induces hypotension in aged spontaneously hypertensive rats (SHRs) and stroke-prone SHRs when administered at a dose of 3 mg/kg.

Uses

OPC 21268 is a nonpeptide AVP (Vasopressin) Receptor V antagonist.

storage

Store at +4°C

OPC 21268 Preparation Products And Raw materials

Raw materials

Preparation Products

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OPC 21268 Suppliers

China 53 United Kingdom 1 United States 11 USA 1 Global 66

131631-89-5, OPC 21268Related Search:


  • 1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one
  • 1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate
  • N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide hydrate
  • OPC-21268 hydrate
  • N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]acetamide
  • OPC 21268
  • N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide
  • OPC 21268;OPC-21268;OPC21268
  • CS-2724
  • Fuscoside
  • Acetamide, N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-
  • Inhibitor,Vasopressin Receptor,OPC21268,Fuscoside,OPC-21268,inhibit
  • 131631-89-5