sandramycin
- Product Name
- sandramycin
- CAS No.
- 100940-65-6
- Chemical Name
- sandramycin
- Synonyms
- sandramycin;L-Valine, N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-, bimol. (5→1'3),(5'→13)-dilactone;3-hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.0^{16,21}]tetracontan-3-yl]quinoline-2-carboxamide
- CBNumber
- CB61357149
- Molecular Formula
- C60H76N12O16
- Formula Weight
- 1221.32
- MOL File
- 100940-65-6.mol
sandramycin Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solid
Safety
- HS Code
- 29419000
N-Bromosuccinimide Price
- Product number
- 20575
- Product name
- Sandramycin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $364
- Updated
- 2024/03/01
- Product number
- 20575
- Product name
- Sandramycin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1210
- Updated
- 2024/03/01
- Product number
- S115303
- Product name
- Sandramycin
- Packaging
- 2.5mg
- Price
- $735
- Updated
- 2021/12/16
- Product number
- S0091-01
- Product name
- Sandramycin
- Packaging
- 1mg
- Price
- $523
- Updated
- 2021/12/16
- Product number
- CS-0016897
- Product name
- Sandramycin
- Packaging
- 1mg
- Price
- $550
- Updated
- 2021/12/16
sandramycin Chemical Properties,Usage,Production
Uses
Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycin class produced by Kribbella sp.. Sandramycin has potent antitumour and antibacterial activity, and is thought to act by bis-intercalation of DNA.
Uses
Sandramycin is a potent antibacterial agent.
Biological Activity
sandramycin is a cyclic depsipeptide antibiotic that was first isolated from cultured broth of a nocardioides sp [1].sandramycin is an antitumor antibiotic. sandramycin was closely related to the cyclic depsipeptides luzopeptins a, b, c and d. sandramycin exhibited strong inhibition to the gram-positive organisms bacillus subtilis, staphylococcus aureus and streptococcusfaecalis. its antimicrobial activity paralleled that which was observed for echinomycin and luzopeptin a [1]. sandramycin was also a bifunctional dna intercalator that strongly binds dna and forms crosslinks between dna molecules [2].in transplantable mouse leukemia p388, sandramycin was moderately active with values comparable to those for luzopeptin a. injection of 2 mg/kg showed the best increase in life span over the controls (61%) [1].
References
[1]. matson ja, bush ja. sandramycin, a novel antitumor antibiotic produced by a nocardioides sp. production, isolation, characterization and biological properties. j antibiot (tokyo). 1989 dec;42(12):1763-7.
[2]. boger dl, saionz kw. dna binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. bioorg med chem. 1999 feb;7(2):315-21.
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