sandramycin

Product Name: sandramycin
CAS No.: 100940-65-6
Chemical Name: sandramycin
Synonyms: sandramycin;L-Valine, N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-, bimol. (5→1'3),(5'→13)-dilactone;3-hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.0^{16,21}]tetracontan-3-yl]quinoline-2-carboxamide
CBNumber: CB61357149
Molecular Formula: C60H76N12O16
Formula Weight: 1221.32
MOL File: 100940-65-6.mol

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sandramycin Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid

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Safety

HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20575
Product name: Sandramycin
Purity: ≥95%
Packaging: 1mg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 20575
Product name: Sandramycin
Purity: ≥95%
Packaging: 5mg
Price: $1210
Updated: 2024/03/01

TRC

Product number: S115303
Product name: Sandramycin
Packaging: 2.5mg
Price: $735
Updated: 2021/12/16

Usbiological

Product number: S0091-01
Product name: Sandramycin
Packaging: 1mg
Price: $523
Updated: 2021/12/16

ChemScene

Product number: CS-0016897
Product name: Sandramycin
Packaging: 1mg
Price: $550
Updated: 2021/12/16

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sandramycin Chemical Properties,Usage,Production

Uses

Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycin class produced by Kribbella sp.. Sandramycin has potent antitumour and antibacterial activity, and is thought to act by bis-intercalation of DNA.

Uses

Sandramycin is a potent antibacterial agent.

Biological Activity

sandramycin is a cyclic depsipeptide antibiotic that was first isolated from cultured broth of a nocardioides sp [1].sandramycin is an antitumor antibiotic. sandramycin was closely related to the cyclic depsipeptides luzopeptins a, b, c and d. sandramycin exhibited strong inhibition to the gram-positive organisms bacillus subtilis, staphylococcus aureus and streptococcusfaecalis. its antimicrobial activity paralleled that which was observed for echinomycin and luzopeptin a [1]. sandramycin was also a bifunctional dna intercalator that strongly binds dna and forms crosslinks between dna molecules [2].in transplantable mouse leukemia p388, sandramycin was moderately active with values comparable to those for luzopeptin a. injection of 2 mg/kg showed the best increase in life span over the controls (61%) [1].

in vivo

Sandramycin (0.0125-1.6?mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice^[1].

Animal Model:	CDF1 female mice injected with leukemia P388 cells^[1]
Dosage:	0.0125?mg/kg, 0.025?mg/kg, 0.05?mg/kg, 0.1?mg/kg, 0.2?mg/kg, 0.4?mg/kg, 0.8?mg/kg, 1.6?mg/kg
Administration:	Intraperitoneal injection; daily; for 5 days
Result:	Was moderately active in vivo against leukemia P388 in mice.

IC 50

Traditional Cytotoxic Agents

References

[1]. matson ja, bush ja. sandramycin, a novel antitumor antibiotic produced by a nocardioides sp. production, isolation, characterization and biological properties. j antibiot (tokyo). 1989 dec;42(12):1763-7.
[2]. boger dl, saionz kw. dna binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. bioorg med chem. 1999 feb;7(2):315-21.

sandramycin Preparation Products And Raw materials

Raw materials

Preparation Products

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sandramycin Suppliers

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100940-65-6, sandramycinRelated Search:

Clindamycin Gentamicin 3-[2-(dimethylamino)ethoxy]-N,N-dimethylpropylamine sandramycin

sandramycin

3-hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8,11,28,31-tetramethyl-2,6,9,12,15,22,26,29,32,35-decaoxo-7,27-di(propan-2-yl)-5,25-dioxa-1,8,11,14,21,28,31,34-octazatricyclo[34.4.0.0^{16,21}]tetracontan-3-yl]quinoline-2-carboxamide

L-Valine, N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-, bimol. (5→1'3),(5'→13)-dilactone

100940-65-6

C60H76N12O16

Antibiotic