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TP 508

Product Name
TP 508
CAS No.
121341-81-9
Chemical Name
TP 508
Synonyms
TP 508;L-Valine, L-alanylglycyl-L-tyrosyl-L-lysyl-L-prolyl-L-α-aspartyl-L-α-glutamylglycyl-L-lysyl-L-arginylglycyl-L-α-aspartyl-L-alanyl-L-cysteinyl-L-α-glutamylglycyl-L-α-aspartyl-L-serylglycylglycyl-L-prolyl-L-phenylalanyl-
CBNumber
CB61363881
Molecular Formula
C97H146N28O36S
Formula Weight
2312.46
MOL File
121341-81-9.mol
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TP 508 Property

Density 
1.56±0.1 g/cm3(Predicted)
InChIKey
MOZAQZCGIKWACU-BRMVNBHNNA-N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7065
Product name
TP508
Packaging
1mg
Price
$144
Updated
2021/12/16
ChemScene
Product number
CS-7065
Product name
TP508
Packaging
5mg
Price
$576
Updated
2021/12/16
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TP 508 Chemical Properties,Usage,Production

Biological Activity

TP508 is a 23 amino acid non-proteolytic thrombin peptide representing part of the receptor binding domain of the thrombin molecule. It activates endothelial NO synthase (eNOS) and stimulates NO production in human endothelial cells. TP508 enables angiogenesis and tissue regeneration by activating endothelial cells and stem cells.

in vitro

TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells.
TP508 mitigates effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation and accelerating repair of radiation-induced DNA double-strand breaks (DSB).
TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through a RGD and αvβ3-related mechanism.

Western Blot Analysis

< td class="col1"> Cell Line:
Primary human coronary artery endothelial cells (HCAEC)
Concentration: 50 μg/mL
Incubation Time: 24 hours
Result: Prevented the radiation-induced downregulation of eNOS.

in vivo

TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure. < /p>

< tr>
Animal Model: Male CD-1 mice (12-15-week old) with γ irradiation
Dosage: 10 mg/kg
Administration: Intravenous injection
Result: Mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice.

TP 508 Preparation Products And Raw materials

Raw materials

Preparation Products

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TP 508 Suppliers

Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
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China
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6968
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58
Shanghai Han-Xiang Chemical Co., Ltd.
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15971444841
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18327183813
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3061
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58
Zhejiang J&C Biological Technology Co.,Limited
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+1-2135480471 +1-2135480471
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sales@sarms4muscle.com
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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0371-86658258
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laboratory@coreychem.com
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China
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Wuxi Helen Biotechnology Co., Ltd.,
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sales@reading-chemicals.com
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Ontores Biotech
Tel
0571-88760729 18072970094
Email
supports@ontorespeptide.com
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2696
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Hangzhou Go Top Peptide Biotech
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0571-88211921 13735575465
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sales1@gotopbio.com
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
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psaitong@jm-bio.com
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Shaoxing Junyu Biotechnology Co., LTD
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Hangzhou Sinoda Pharmaceutical Technology Co. LTD
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Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
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0571-85350119 15888826472
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15888826472@163.com
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Shanghai HongTide Biotechnology Co.,Ltd.
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19961912513
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Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
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Combio (Suzhou) Ltd.
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Zhejiang Jiekun Biotechnology Co., Ltd
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Hangzhou Beiputai Biopharmaceutical Co., Ltd
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Changsha MOL Changes Biotechnology Co., Ltd.
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info@molchanges.com
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Shenzhen Nexconn Pharmatechs Ltd
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+86-755-89396905 +86-15013857715
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admin@nexconn.com
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Zhejiang Hangyu API Co., Ltd
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Hebei Miaoyin Technology Co.,Ltd
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Beijing Dongge Boye Biotechnology Co., Ltd.
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Shanghai Qiming Biological Technology Co., Ltd.
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Hongtuo Biotechnology Co., Ltd.
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Beijing Huaxia Ocean Technology Co., Ltd.
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Guangzhou Weijia Technology Co., Ltd.
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View Lastest Price from TP 508 manufacturers

Hebei Yalin Technology Co., Ltd
Product
TP508 121341-81-9
Price
US $20.00-9000.00/vial
Min. Order
10vial
Purity
99.99%
Supply Ability
90000kit
Release date
2023-08-24

121341-81-9, TP 508Related Search:


  • TP 508
  • L-Valine, L-alanylglycyl-L-tyrosyl-L-lysyl-L-prolyl-L-α-aspartyl-L-α-glutamylglycyl-L-lysyl-L-arginylglycyl-L-α-aspartyl-L-alanyl-L-cysteinyl-L-α-glutamylglycyl-L-α-aspartyl-L-serylglycylglycyl-L-prolyl-L-phenylalanyl-
  • 121341-81-9