20,22-dihydroxycholesterol
- Product Name
- 20,22-dihydroxycholesterol
- CAS No.
- 596-94-1
- Chemical Name
- 20,22-dihydroxycholesterol
- Synonyms
- Oxy-16;Oxy-16, Oxysterol;20,22-dihydroxycholesterol;ISBSSBGEYIBVTO-RCXKVKFCSA-N;(3β,22R)-Dihydroxy Cholesterol;20α,22(R)-Dihydroxycholesterol;(3β,22R)-Dihydroxy Cholesterol;(20R,22R)-Dihydroxycholesterol;(22R)-5-Cholesten-3β,20α,22-triol;(22R)-Cholest-5-ene-3β,20,22-triol
- CBNumber
- CB61372988
- Molecular Formula
- C27H46O3
- Formula Weight
- 418.65
- MOL File
- 596-94-1.mol
20,22-dihydroxycholesterol Property
- Melting point:
- 183 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 553.5±25.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤10mg/ml in ethanol;1.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 14.42±0.29(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9000395
- Product name
- Oxy-16
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 9000395
- Product name
- Oxy-16
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $537
- Updated
- 2024/03/01
- Product number
- 9000395
- Product name
- Oxy-16
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $952
- Updated
- 2024/03/01
- Product number
- D452465
- Product name
- (3β,22R)-DihydroxyCholesterol
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 1673AH
- Product name
- Cholest-5-ene-3beta,20,22R-triol
- Packaging
- 1mg
- Price
- $232
- Updated
- 2021/12/16
20,22-dihydroxycholesterol Chemical Properties,Usage,Production
Description
Naturally occurring oxysterols are products of cholesterol oxidation that can stimulate the hedgehog (Hh) signaling pathway in target cells associated with cardiovascular disease and with bone formation. Depending on the target cell, activation of Hh signaling can modulate inflammatory responses to additional atherogenic factors such as lesion-
Uses
A metabolite of Cholesterol (C432501). Cholesterol is metabolized to Pregnenolone by way of 22R-hydroxycholesterol and 20R,22R-dihydroxycholesterol by P 450scc.
Definition
ChEBI: An oxysterol that is cholesterol substituted by hydroxy groups at positions 20 and 22 (the 20R,22R-stereoisomer).
in vitro
oxysterols have been shown to be associated with immunosuppression, apoptosis, atherosclerosis, inflammation, and cholesterol turnover. other studies aslo indicated that oxysterols were hedgehog (hh) signaling pathway activators and had potent osteoinductive properties. oxy-16, an oxysterol, was identified as a cell permeable oxygenated derivative of cholesterol that might be the end product or intermediate of the cholesterol excretion pathways. oxy-16 is currently used as a transport form for cholesterol across the blood brain barrier and membranes. the osteogenic differentiation caused by oxy-16 was cinsidered to be mediated via a wnt signaling-related, dkk-1-inhibitable mechanism [1].
References
[1] amantea, c. m.,kim, w.k.,meliton, v., et al. oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by dkk-1 inhibitable and pi3-kinase mediated signaling. journal of cellular biochemistry 105(2), 424-436 (2008).
20,22-dihydroxycholesterol Preparation Products And Raw materials
Raw materials
Preparation Products
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