CP 471,474
- Product Name
- CP 471,474
- CAS No.
- 210755-45-6
- Chemical Name
- CP 471,474
- Synonyms
- CP 471,474;PF-1626077;2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide;2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide;Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
- CBNumber
- CB61389258
- Molecular Formula
- C16H17FN2O5S
- Formula Weight
- 368.38
- MOL File
- 210755-45-6.mol
CP 471,474 Property
- Melting point:
- 135-137°C (dec.)
- Density
- 1.375±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: ≥20mg/mL
- pka
- 9.33±0.50(Predicted)
- form
- powder
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PZ0137
- Product name
- CP-471474
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- PZ0137
- Product name
- CP-471474
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $404
- Updated
- 2024/03/01
- Product number
- 29442
- Product name
- CP 471,474
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29442
- Product name
- CP 471,474
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 29442
- Product name
- CP 471,474
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
CP 471,474 Chemical Properties,Usage,Production
Description
CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.
Chemical Properties
White Solid
Uses
A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
Biochem/physiol Actions
CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
CP 471,474 Preparation Products And Raw materials
Raw materials
Preparation Products
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