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dolastatin 10

Product Name
dolastatin 10
CAS No.
110417-88-4
Chemical Name
dolastatin 10
Synonyms
DLS 10;CS-1367;Nsc376128;Dolastain10;B720389K560;dolastatin 10;Dolastatin 10 (NSC-376128);Dolastatin 10,DLS 10,NSC 376128;From dolabella auricularia (sea hare);Dolastatin 10,DLS 10,NSC 376128, >99%
CBNumber
CB61390632
Molecular Formula
C42H68N6O6S
Formula Weight
785.09
MOL File
110417-88-4.mol
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dolastatin 10 Property

Melting point:
107~112
Boiling point:
903.6±65.0 °C(Predicted)
Density 
1.116±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C,unstable in solution, ready to use.
solubility 
≥78.5 mg/mL in EtOH; insoluble in H2O; ≥67.2 mg/mL in DMSO
form 
Powder
pka
13.81±0.46(Predicted)
color 
White to off-white
optical activity
-6829 (methanol)
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Safety

RIDADR 
3172
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-1825
Product name
Dolastatin10
Purity
98.52%
Packaging
1mg
Price
$300
Updated
2021/12/16
ApexBio Technology
Product number
B1035
Product name
Dolastatin10
Packaging
1mg
Price
$523
Updated
2021/12/16
ChemScene
Product number
CS-1825
Product name
Dolastatin10
Purity
98.52%
Packaging
5mg
Price
$800
Updated
2021/12/16
ApexBio Technology
Product number
B1035
Product name
Dolastatin10
Packaging
5mg
Price
$1425
Updated
2021/12/16
CSNpharm
Product number
CSN17468
Product name
Dolastatin10
Packaging
1mg
Price
$279
Updated
2021/12/16
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dolastatin 10 Chemical Properties,Usage,Production

Definition

ChEBI: Dolastatin 10 is a tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization. It has a role as an animal metabolite, a marine metabolite, an antineoplastic agent, an apoptosis inducer and a microtubule-destabilising agent. It is a member of 1,3-thiazoles and a tetrapeptide. It is functionally related to a L-valine.

Biological Activity

dolastatin 10 is an antitumor agent [1].dolastatin 10 is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. dolastatin 10 is found to have activity to inhibit tubulin polymerization with ic50 value of 1.2μm. besides that, it potently inhibits vincristine binding to tubulin with a ki value of 1.4μm in a noncompetitive manner. dolastatin 10 also shows moderate effect on enhancing the binding of colchicines to tubulin. in addition, dolastatin 10 has the inhibitory activity in tubulin-dependent gtp binding [1].in the cellular assay, dolastatin 10 shows activity against some human leukaemia, lymphoma and solid tumour cell lines (such as ovcar-3 and nsclc) with ic50 values ranging from 0.1nm to 10nm. it is currently tested in the

in vitro

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI < sub> 50 values of 10 ?5 -10 ?6 μg/mL (10 ?2 -10 ? 3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.

target

Auristatin

References

[1] bai r l, pettit g r, hamel e. binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. journal of biological chemistry, 1990, 265(28): 17141-17149.
[2] schwartsmann g. marine organisms and other novel natural sources of new cancer drugs. annals of oncology, 2000, 11(suppl 3): 235-243.

dolastatin 10 Preparation Products And Raw materials

Raw materials

Preparation Products

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dolastatin 10 Suppliers

Alabiochem Tech.Co., Ltd.
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0086-512-56765862
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sales@alabiochem.com
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China
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Artis Chemistry (Shanghai) Co. Ltd.
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86-21-60936353
Fax
86-21-60936352
Country
China
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Shanghai Topbiochem Technology Co., Ltd
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021-58170097
Email
info@topbiochem.com
Country
China
ProdList
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Tianjin Chempharmatech Co.,Ltd.
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022-66211079 13212288319
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Hangzhou Peptide Biochem Co.,Ltd
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0571-89197072; 18668118770
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LETOPHARM LIMITED
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Shanghai Lollane Biological Technology Co.,Ltd.
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ALB Technology Limited
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