Ro 32-3555
- Product Name
- Ro 32-3555
- CAS No.
- 190648-49-8
- Chemical Name
- Ro 32-3555
- Synonyms
- Ro 32-3555;(αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide;1-Piperidinebutanamide, β-(cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-, (αR,βR)-
- CBNumber
- CB61394281
- Molecular Formula
- C22H36N4O5
- Formula Weight
- 436.54504
- MOL File
- 190648-49-8.mol
Ro 32-3555 Property
- Melting point:
- >156°C (Dec.)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.16±0.40(Predicted)
- color
- Light Beige to Beige
N-Bromosuccinimide Price
- Product number
- R700905
- Product name
- Ro32-3555
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- API0011050
- Product name
- CIPEMASTAT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.19
- Updated
- 2021/12/16
Ro 32-3555 Chemical Properties,Usage,Production
Uses
Cartilage protec- tive agent in rheumatoid arthritis.
Uses
Ro 32-3555 is an orally active collagenase inhibitor that prevents cartilage breakdown. It is used for the treatment of arthritis.
in vivo
The amount of hydroxyproline in non-implanted cartilage is 119.3±4.2 nM/mg and this decreases in cartilages implanted in vehicle-dosed animals to 53.6±7.1 nM/mg over a fourteen day period. Animals administered Cipemastat orally at doses of 2.5, 5, 10 and 25 mg/kg show statistically increased levels of implanted cartilage hydroxypro-line. Fourteen days after the second challenge injection of P. acnes, the area of cartilage most consistently affected by pannus is the lateral femoral condyle, which is the area analysed. In non-arthritic animals the mean cartilage area is 0.17±0.02 mm2 (n=5). In arthritic animals there is a significant decrease to a mean area of 0.086±0.01 mm2 (n=10). The group of animals dosed with Cipemastat (50 mg/kg, p.o.) show a significantly greater area of cartilage with a mean value of 0.126±0.012 mm2 (n=9). The pannus area in vehicle-dosed animals is 0.099±0.017 mm2 and in Cipemastat dosed animals 0.102±0.019 mm2. Adjuvant arthritis injection of adjuvant induced two phases of swelling of the injected paw in vehicle-dosed rats. The primary swelling phase occurred between days 0 to 5 and induced an increase in paw volume of 1.9±0.1 mL; the secondary phase occurrs between day 9 to 14 and there was an increase in paw swelling of 0.98±0.08 mL. The group of animals dosed with dexamethasone (0.1 mg/kg) shows a significant reduction in both primary (0.2±0.03 mL) and secondary inflammation (0.07±0.08 mL) paw swelling as well as total inhibition of the lesion score[1].
IC 50
collagenases 1: 3.0 nM (Ki); collagenases 2: 4.4 nM (Ki); collagenases 3: 3.4 nM (Ki); stromelysins 1: 527 nM (Ki); gelatinase A: 154 nM (Ki); gelatinase B: 59.1 nM (Ki)
Ro 32-3555 Preparation Products And Raw materials
Raw materials
Preparation Products
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