Ro 60-0175
- Product Name
- Ro 60-0175
- CAS No.
- 169675-08-5
- Chemical Name
- Ro 60-0175
- Synonyms
- Ro 60-0175;Ro60-0175, 10 mM in DMSO;(S)-1-(6-Chloro-5-fluoro-1H-indol-1-yl)propan-2-amine;(2S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine;1H-Indole-1-ethanamine, 6-chloro-5-fluoro-α-methyl-, (αS)-;(aS)-6-Chloro-5-fluoro-a-methyl-1H-indole-1-ethanamine monofumarate;selective,cocaine,Inhibitor,Ro600175,contextual cues,inhibit,yohimbine,5-hydroxytryptamine Receptor,5-HT2C,Ro60 0175,Ro-60-0175,drug-seeking,self-administration,5-HT Receptor,Serotonin Receptor
- CBNumber
- CB61398744
- Molecular Formula
- C11H12ClFN2
- Formula Weight
- 226.68
- MOL File
- 169675-08-5.mol
Ro 60-0175 Property
- Boiling point:
- 353.2±32.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 125 mg/mL (551.44 mM; Need ultrasonic)
- pka
- 9.58±0.10(Predicted)
- form
- Solid
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
Ro 60-0175 Chemical Properties,Usage,Production
Uses
Ro60-0175 is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 reduces self-administration[1].
Definition
ChEBI: (2S)-1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine is a 1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine that has S configuration. A selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. It has a role as a 5-hydroxytryptamine 2B receptor agonist and a 5-hydroxytryptamine 2C receptor agonist.
in vivo
Ro60-0175 (1 mg/kg; s.c.) preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1].
Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) significantly reduces responding on the active lever in the reinstatement group[1].
Ro60-0175 (0.5 mg/kg SB242084; 1 mg/kg Ro60-0175; s.c.; i.p.) reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1].
| Animal Model: | Adult male Sprague-Dawley rats (280-320 g)[1] |
| Dosage: | 1 mg/kg |
| Administration: | s.c. |
| Result: | Preserved the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reached their break-points earlier. |
| Animal Model: | Adult male Sprague-Dawley rats (280-320 g)[1] |
| Dosage: | 0.5mg/kg (SB242084), 1mg/kg (Ro60-0175) |
| Administration: | s.c. (Ro60-0175), i.p. (SB242084) |
| Result: | Reduced responding for cocaine and effect was reversed by SB242084. |
| Animal Model: | Adult male Sprague-Dawley rats (280-320 g)[1] |
| Dosage: | 0.3, 1, and3 mg/kg (Ro60-0175), 1mg/kg (yohimbine) |
| Administration: | s.c. (Ro60-0175), i.p. (yohimbine) |
| Result: | Showed yohimbine treatment alone increased responding relative to vehicle injection, and the response was attenuated dose dependently by Ro60-0175. |
| Animal Model: | Adult male Sprague-Dawley rats (280-320 g)[1] |
| Dosage: | 0.5 mg/kg (SB242084), 1mg/kg (Ro60-0175), 1mg/kg (yohimbine) |
| Administration: | s.c. (Ro60-0175), i.p. (yohimbine), i.p. (SB242084) |
| Result: | Ro60-0175 reduced responding and that this effect was prevented by SB242084 pretreatment. |
IC 50
5-HT2C Receptor
References
[1] Fletcher PJ, et al. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008;33(6):1402-1412. DOI:10.1038/sj.npp.1301509
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