1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
- Product Name
- 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
- CAS No.
- 112037-78-2
- Chemical Name
- 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
- Synonyms
- -carboline;3-Methyl αNorharmane (9H-Pyrido[3,4-b]indole, ß1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ßrac 1-Trichloromethyl-1,2,3,4-Tetrahydro-β(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-β1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline;1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE;1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE;1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline
- CBNumber
- CB6140573
- Molecular Formula
- C12H11F3N2
- Formula Weight
- 240.22
- MOL File
- 112037-78-2.mol
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Property
- Melting point:
- 147-149°C
- Boiling point:
- 350.0±37.0 °C(Predicted)
- Density
- 1.351±0.06 g/cm3(Predicted)
- pka
- 16.63±0.40(Predicted)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
N-Bromosuccinimide Price
- Product number
- HCH0016529
- Product name
- 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.91
- Updated
- 2021/12/16
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Chemical Properties,Usage,Production
Mechanism of action
Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.
Clinical Use
Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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