5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE

Product Name: 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE
CAS No.: 5900-13-0
Chemical Name: 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE
Synonyms: 5-BROMO-3-METHOXYPYR;5-BroMo-3-MethoxypyrazinaMine;2-Amino-5-Bromo-3-methoxypyra;5-bromo-3-methoxypyrazin-2-amine;2-Amino-5-Bromo-3-methoxypyrazin;5-Bromo-3-methoxy-2-pyrazinamine;3-Methoxy-5-bromopyrazin-2-amine;2-AMINO-5-BROMO-3-METHOXYPYRAZINE;2-Amino-3-methoxy-5-bromopyrazine;2-PyrazinaMine, 5-broMo-3-Methoxy-
CBNumber: CB6145518
Molecular Formula: C5H6BrN3O
Formula Weight: 204.02
MOL File: 5900-13-0.mol

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5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE Property

Melting point:: 135-140 °C
Boiling point:: 262 ºC
Density: 1.723
refractive index: 1.
Flash point:: 112 ºC
storage temp.: 2-8°C
solubility: DMSO, Methanol
form: Solid
pka: 1.93±0.10(Predicted)
color: Off-White
InChIKey: QDFJJHGAODFQMN-UHFFFAOYSA-N
CAS DataBase Reference: 5900-13-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 732125
Product name: 2-Amino-5-bromo-3-methoxypyrazine
Purity: 95%
Packaging: 500mg
Price: $73.2
Updated: 2023/01/07

TCI Chemical

Product number: A2562
Product name: 2-Amino-5-bromo-3-methoxypyrazine
Purity: >99.0%(GC)(T)
Packaging: 1g
Price: $48
Updated: 2025/07/31

TRC

Product number: B684815
Product name: 5-Bromo-3-methoxy-2-pyrazinamine
Packaging: 5g
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB54437
Product name: 5-Bromo-3-methoxypyrazin-2-amine
Packaging: 1g
Price: $181.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB54437
Product name: 5-Bromo-3-methoxypyrazin-2-amine
Packaging: 2g
Price: $290.4
Updated: 2021/12/16

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5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

5-Bromo-3-methoxy-2-pyrazinamine is an intermediate in the preparation of N-pyrazinylbenzenesulfonamides used in treatment of chemokine mediated diseases such as asthma.

Synthesis

124-41-4

24241-18-7

5900-13-0

1. A 30% w/w methanolic solution of sodium methanolate (8.4 mL, 44.8 mmol) was slowly added to a stirring suspension of 3,5-dibromo-2-aminopyrazine (10 g, 39.5 mmol) in anhydrous methanol (40 mL). 2. The reaction mixture was heated to reflux and the reaction was maintained for 3 h. 3. Upon completion of the reaction, the reaction was cooled to room temperature and concentrated to 1/3 of the original volume by rotary evaporation. 4. The concentrated reaction mixture was partitioned between dichloromethane (DCM) and saturated aqueous sodium bicarbonate (NaHCO3).5 The organic and aqueous layers were separated and the organic phase was washed three times with saturated aqueous NaHCO3.6 The aqueous phases were combined and back-extracted three times with DCM.7 All the organic phases were combined, washed with saturated saline, dried with anhydrous sodium sulfate, filtered, and concentrated to give 5 mL of the reaction mixture.8 The reaction mixture was then dried. dried, filtered and concentrated to give 5-bromo-3-methoxypyrazin-2-amine (8.1 g). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.64 (s, 1H), 4.79 (br s, 2H), 4.01 (s, 3H).

References

[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 9, p. 981 - 986
[2] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 5, p. 1149 - 1154
[3] Patent: US2013/210818, 2013, A1. Location in patent: Paragraph 0384
[4] Patent: WO2014/68171, 2014, A1. Location in patent: Page/Page column 27
[5] Patent: WO2009/115572, 2009, A2. Location in patent: Page/Page column 116

5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE Suppliers

Americas 1 Canada 1 China 174 Czech Republic 1 Europe 1 Germany 2 India 3 Japan 1 United Kingdom 5 United States 16 Global 205

J & K SCIENTIFIC LTD.

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Energy Chemical

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View Lastest Price from 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Bromo-3-methoxypyrazin-2-amine 5900-13-0
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1000kg
Release date: 2025-06-13

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-5-bromo-3-methoxypyrazine 5900-13-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-29

Career Henan Chemical Co

Product: 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE 5900-13-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

5900-13-0, 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINERelated Search:

5-Bromo-2-methoxyphenol 2-Methoxy-3-methylpyrazine 5-BROMO-3-(1-ETHYLPROPOXY)-N-METHYLPYRAZIN-2-AMINE 2-AMINO-5-BROMO-3-ETHOXYPYRAZINE 2-AMINO-3-BENZYLOXY-5-BROMOPYRAZINE 2-[3-BROMO-5-(1-ETHYLPROPOXY)-6-(METHYLAMINO)PYRAZIN-2-YL]-5-(TRIFLUOROMETHOXY)PHENOL 5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE 5-BROMO-N-(1-ETHYLPROPYL)-3-METHOXY-6-METHYLPYRAZIN-2-AMINE 5-BROMO-6-CHLORO-3-METHOXYPYRAZIN-2-AMINE

2-AMINO-5-BROMO-3-METHOXYPYRAZINE

5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE

5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE, 95+%

3-Methoxy-5-bromopyrazin-2-amine

5-Bromo-3-methoxy-2-pyrazinamine

2-Amino-5-Bromo-3-methoxypyrazin

5-BROMO-3-METHOXYPYR

5-bromo-3-methoxypyrazin-2-amine

2-aiMino-5-broMo-3-Methoxypyrazine

2-PyrazinaMine, 5-broMo-3-Methoxy-

5-BroMo-3-MethoxypyrazinaMine

5-Bromo-3-methoxypyrazin-2-amine, 2-Amino-5-bromo-3-methoxy-1,4-diazine

2-Amino-5-Bromo-3-methoxypyra

2-Amino-3-methoxy-5-bromopyrazine

2-Amino-5-bromo-3-methoxypyrazine &gt

5-amino-6-methoxypyrazine-2-carbonitrile

5-BROMO-3-METHOXYPYRAZIN-2-YLAMINE ISO 9001：2015 REACH

5900-13-0

amine|alkyl bromide