1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE

Product Name: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
CAS No.: 5755-07-7
Chemical Name: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
Synonyms: 1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one;2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-;2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one - [T28673]
CBNumber: CB61466427
Molecular Formula: C9H10N2O
Formula Weight: 162.19
MOL File: 5755-07-7.mol

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1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE Property

Melting point:: 140.5-141.5 °C
Boiling point:: 376.1±31.0 °C(Predicted)
Density: 1.137±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.80±0.20(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T324922
Product name: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $148
Updated: 2025/07/31

Sigma-Aldrich

Product number: T324922
Product name: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
Purity: AldrichCPR
Packaging: 5MG
Price: $144
Updated: 2024/03/01

TRC

Product number: T293015
Product name: 1,3,4,5-Tetrahydro-2H-1,5-benzodiazepin-2-one
Packaging: 2.5g
Price: $1100
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0005837
Product name: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
Purity: 95.00%
Packaging: 2.5G
Price: $1815
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0005837
Product name: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
Purity: 95.00%
Packaging: 250MG
Price: $721.88
Updated: 2021/12/16

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1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE Chemical Properties,Usage,Production

Uses

A tetrahydrobenzodiazepine derivative as arginine vasopressin antagonist.

Synthesis

1270914-58-3

5755-07-7

The general procedure for the synthesis of 1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one from the compound (CAS: 1270914-58-3) is as follows: Step 3: Synthesis of 4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one 1. methanol (1.8 g, 77.2 mmol) was added in batches to methanol (50 mL) at 0 °C and the mixture was stirred for 1 hour. 2. the above mixture was added dropwise to a solution of methyl 3-((2-aminophenyl)amino)propionate (9.4 g, 48.2 mmol) in methanol (150 mL), keeping the temperature at 0 °C. the mixture was then stirred for 1 h. The mixture was then added to the methanol (50 mL) by dropwise addition. 3. After completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. 4. The reaction mixture was concentrated and the residue was purified by CombiFlash fast column chromatography (eluent: petroleum ether/ethyl acetate = 5:1) to afford 4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one as a yellow solid (3.9 g, 50% yield). Product Characterization: - LRMS (M + H)+: m/z 161 - 1H NMR (300 MHz, CD3OD): δ 2.61 (t, J = 6.0 Hz, 2H), 3.62 (t, J = 6.0 Hz, 2H), 6.76-6.86 (m, 2H), 6.90-6.99 (m, 2H).

References

[1] Patent: WO2012/151512, 2012, A2. Location in patent: Page/Page column 113-114
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 2, p. 145 - 150

1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE Suppliers

Canada 1 China 35 India 3 United States 4 Global 43

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5755-07-7, 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONERelated Search:

1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one

2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-

2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one - [T28673]

5755-07-7

Aromatics

Heterocycles