6-Amino-2,3-dibromopyridine
- Product Name
- 6-Amino-2,3-dibromopyridine
- CAS No.
- 89284-11-7
- Chemical Name
- 6-Amino-2,3-dibromopyridine
- Synonyms
- 5,6-Dibromo-2-pyridinamine;6-Amino-2,3-dibromopyridine;2-Pyridinamine, 5,6-dibromo-;5,6-DibroMo-pyridin-2-ylaMine;5,6-Dibromo-2-pyridinamine 97%
- CBNumber
- CB61471298
- Molecular Formula
- C5H4Br2N2
- Formula Weight
- 251.91
- MOL File
- 89284-11-7.mol
6-Amino-2,3-dibromopyridine Property
- Melting point:
- 154-155 °C(Solv: benzene (71-43-2))
- Boiling point:
- 298.1±35.0 °C(Predicted)
- Density
- 2.147±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.19±0.10(Predicted)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C5H4Br2N2/c6-3-1-2-4(8)9-5(3)7/h1-2H,(H2,8,9)
- InChIKey
- SETWFMYLBKUBKF-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Br)=C(Br)C=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D424745
- Product name
- 5,6-Dibromopyridin-2-amine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J97230
- Product name
- 5,6-Dibromo-2-pyridinamine
- Packaging
- 250mg
- Price
- $33
- Updated
- 2021/12/16
- Product number
- X7974
- Product name
- 5,6-Dibromo-2-pyridinamine
- Packaging
- 250mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- FD43385
- Product name
- 5,6-Dibromo-2-pyridinamine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD43385
- Product name
- 5,6-Dibromo-2-pyridinamine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
6-Amino-2,3-dibromopyridine Chemical Properties,Usage,Production
Synthesis
19798-81-3
89284-11-7
Under argon protection, 6-bromopyridin-2-amine (5 g, 28.90 mmol) was dissolved in DMF (75 mL) and stirred at 0 °C. To this solution, N-bromosuccinimide (35 mg, 1.04 mmol) was slowly added. The reaction mixture was gradually warmed up to room temperature and stirred continuously for 16 hours. The progress of the reaction was monitored by TLC and after confirming complete consumption of the feedstock, the reaction was quenched with ice-cold water (50 mL). Subsequently, the reaction mixture was extracted with EtOAc (2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: 30% EtOAc/hexane) to afford 5,6-dibromopyridin-2-amine (6.1 g, 85% yield) as an off-white solid. The structure of the product was confirmed by 1H-NMR (CDCl3, 400 MHz) and LCMS: 1H-NMR δ 7.51 (d, 1H), 6.32 (d, 1H), 4.60 (br s, 2H); LCMS m/z 252.6 (M + 1); Chromatographic conditions: X-Select CSH C-18 column (50×3.0 mm, 3.5 μm ), mobile phase 0.05% trifluoroacetic acid aqueous solution/acetonitrile, flow rate 0.80 mL/min, retention time 3.04 min.
References
[1] Patent: CN107778302, 2018, A. Location in patent: Paragraph 0101-0103
[2] Patent: WO2005/100353, 2005, A1. Location in patent: Page/Page column 21
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 5, p. 1697 - 1700
[4] Patent: WO2015/109109, 2015, A1. Location in patent: Paragraph 0710
[5] Patent: US2017/44182, 2017, A1. Location in patent: Paragraph 0982
6-Amino-2,3-dibromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Amino-2,3-dibromopyridine manufacturers
- Product
- 6-Amino-2,3-dibromopyridine 89284-11-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 6-Amino-2,3-dibromopyridine 89284-11-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 6-Amino-2,3-dibromopyridine 89284-11-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10