(Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate
- Product Name
- (Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate
- CAS No.
- 317336-73-5
- Chemical Name
- (Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate
- Synonyms
- TB-1846;tert-butyl 2,3,6,7-tetrahydroazepine-1-carboxylate;tert-butyl 2,3,6,7-tetrahydro-1H-azepine-1-carboxylate;(Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate;tert-Butyl 2,3,6,7-tetrahydro-1H-azepine-1-carboxylate 96%;(Z)-tert-butyl 2,3,6,7-tetrahydro-1H-azepine-1-carboxylate;2,3,6,7-Tetrahydroazepine-1-carboxylic acid tert-butyl ester;1H-Azepine-1-carboxylic acid, 2,3,6,7-tetrahydro-, 1,1-dimethylethyl ester
- CBNumber
- CB61481761
- Molecular Formula
- C11H19NO2
- Formula Weight
- 197.27
- MOL File
- 317336-73-5.mol
(Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate Property
- Boiling point:
- 262.2±29.0 °C(Predicted)
- Density
- 1.007±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.37±0.20(Predicted)
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B814388
- Product name
- (Z)-tert-Butyl2,3,6,7-tetrahydroazepine-1-carboxylate
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FB147496
- Product name
- (Z)-tert-Butyl2,3,6,7-tetrahydroazepine-1-carboxylate
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB147496
- Product name
- (Z)-tert-Butyl2,3,6,7-tetrahydroazepine-1-carboxylate
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CHM0394425
- Product name
- (Z)-TERT-BUTYL 2,3,6,7-TETRAHYDROAZEPINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.97
- Updated
- 2021/12/16
- Product number
- 118305
- Product name
- tert-Butyl 2,3,6,7-tetrahydro-1H-azepine-1-carboxylate
- Packaging
- 1g
- Price
- $545
- Updated
- 2021/12/16
(Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
1211531-07-5
317336-73-5
The general procedure for the synthesis of tert-butyl 2,3,6,7-tetrahydroazepine-1-carboxylate from tert-butyl bis(but-3-en-1-yl)carbamate was as follows: 500 mL of dichloromethane (DCM) was added to a 1 L round-bottomed flask equipped with a reflux condenser, followed by the addition of tert-butyl bis(but-3-en-1-yl)carbamate (1.00 g, 4.44 mmol). The operation was carried out with reference to the method described by Kuhn, KM et al. in Organic Letters, Vol. 12, No. 5, 2010, pp. 984-987. After heating the reaction solution to 45 °C, Grubbs first generation catalyst (238 mg, 0.289 mmol) was added. The reaction mixture was refluxed at 45 °C for 2 hours. After completion of the reaction, the solvent was removed using a rotary evaporator. The product was purified by column chromatography with the eluent being a hexane solution containing 4% ethyl acetate, resulting in 790 mg (4.01 mmol, 9% yield) of tert-butyl 2,3,6,7-tetrahydroazepine-1-carboxylate as an oil.
References
[1] Organic Letters, 2010, vol. 12, # 5, p. 984 - 987
[2] Patent: WO2016/164565, 2016, A1. Location in patent: Page/Page column 9
(Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate manufacturers
- Product
- (Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate 317336-73-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20