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BOC-HYP(BZL)-OH

Product Name
BOC-HYP(BZL)-OH
CAS No.
54631-81-1
Chemical Name
BOC-HYP(BZL)-OH
Synonyms
BOC-HYP(BZL);BOC-HYP(BZL)-OH;BOC-L-HYP(BZL)-OH;Boc-Hyp(Bzl)·DCHA;BOC-PRO(4-OBZL)-OH;BOC-HYP(BZL)-OH DCHA;Boc-L-Hyp(Bzl)-OH·DCHA;BOC-HYP(BZL)-OH·DCHA,98%;BOC-HYP(BZL)-OH USP/EP/BP;BOC-HYDROXYPROLINE(BZL)-OH
CBNumber
CB6148544
Molecular Formula
C17H23NO5
Formula Weight
321.37
MOL File
54631-81-1.mol
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BOC-HYP(BZL)-OH Property

Melting point:
~70 °C
Boiling point:
461.3±45.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
3.75±0.40(Predicted)
Appearance
White to off-white Solid
optical activity
[α]20/D 40±2°, c = 2% in ethanol
BRN 
5296858
CAS DataBase Reference
54631-81-1(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15535
Product name
Boc-Hyp(Bzl)-OH
Purity
≥98.0% (HPLC)
Packaging
5g
Price
$261
Updated
2022/05/15
Usbiological
Product number
264602
Product name
Boc-O-benzyl-L-trans-4-hydroxyproline
Packaging
2g
Price
$360
Updated
2021/12/16
Usbiological
Product number
236621
Product name
Boc-O-benzyl-L-trans-4-hydroxyproline dicyclohexylammonium salt 99+%
Packaging
1g
Price
$179
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0000905
Product name
BOC-HYP(BZL)-OH
Purity
95.00%
Packaging
1G
Price
$154.35
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB46922
Product name
Boc-O-benzyl-L-trans-4-hydroxyproline
Packaging
5G
Price
$173
Updated
2021/12/16
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BOC-HYP(BZL)-OH Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Boc-Hyp(Bzl)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

136024-60-7

40350-83-2

General procedure for the synthesis of 4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid from 1-(tert-butyl) 2-methyl (2S,4R)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylic acid ester: lithium hydroxide was added to a mixture of THF and H2O (60 mL, 2:1, v/v/v/v/v) of compound 2 (3.45 g, 10.29 mmol) monohydrate (1.29 g, 30.87 mmol). The reaction mixture was stirred at room temperature for 3 hours. After the completion of the reaction was monitored by TLC, the reaction mixture was concentrated under reduced pressure, acidified to pH < 7 with 1N hydrochloric acid solution and subsequently extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, washed with saturated sodium chloride solution (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by grinding with pentane (20 mL) to give compound 3 (3.21 g, 97% yield) in white solid form. Mass spectrum (ESI) m/z 322 [M+H]+.

References

[1] Patent: US9994614, 2018, B2. Location in patent: Page/Page column 51; 52; 53
[2] Patent: WO2012/146666, 2012, A1. Location in patent: Page/Page column 206

BOC-HYP(BZL)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-HYP(BZL)-OH Suppliers

China 117 Germany 4 India 1 Japan 4 Switzerland 2 United Kingdom 5 United States 21 Global 154
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
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View Lastest Price from BOC-HYP(BZL)-OH manufacturers

Career Henan Chemical Co
Product
BOC-HYP(BZL)-OH 54631-81-1
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-30

54631-81-1, BOC-HYP(BZL)-OHRelated Search:

H-Arg(Boc)2-pNA H-Arg(Boc)2-AMC L-BETA-HOMOLEUCINE HYDROCHLORIDE FMOC-L-BETA-HOMOLEUCINE Bis(H-Arg(Boc)2)-rhodaMine 110 BOC-L-BETA-HOMOLEUCINE Z-HOMOARGININE BOC-HOMOARGININE (NO2) BOC-HYP-OET FMOC-HYP(BZL)-OH BOC-HYP(BZL)-OH L-Hydroxyproline L-Proline Dicyclohexylamine Fmoc-Hyp(tBu)-OH (2S,4R)-BOC-4-(2-NAPHTHYLMETHOXY)-PYRROLIDINE-2-CARBOXYLIC ACID FMOC-L-HYP(BOM)-OH (2S,4R)-1-BOC-4-BENZYLOXY-PYRROLIDINE-2-DICARBOXYLIC ACID METHYL ESTER

  • (4R)-1-Boc-4-(phenylmethoxy)-L-proline
  • Boc-Hyp(Bzl)-OH >=98.0% (HPLC)
  • BOC-HYP(BZL)-OH·DCHA,98%
  • Boc-O-benzyl-L-trans-4-hydroxyproline≥ 98% (HPLC)
  • Boc-L-Hyp(Bzl)-OH·DCHA
  • Boc-O-benzyl-L-trans-4-hydroxyproline dicyclohexylammonium salt99%
  • T-BUTYLOXYCARBONYL-O-BENZYL-L-HYDROXYPROLINE
  • 4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-(phenylmethyl) ester
  • N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-HYDROXYPROLINE
  • N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-TRANS-4-HYDROXY-L-PROLINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-O-BENZYL-HYDROXYPROLINE
  • BOC-PRO(4-OBZL)-OH
  • BOC-O-BENZYL-L-4-HYDROXYPROLINE
  • BOC-O-BENZYL-L-4-TRANS-HYDROXYPROLINE
  • BOC-O-BENZYL-L-4-TRANS-HYDROXYPROLINE DICYCLOHEXYLAMMONIUM SALT
  • BOC-O-BENZYL-4-HYDROXY-L-PROLINE(TRANS)
  • BOC-O-BENZYL-4-L-HYDROXYPROLINE DICYCLOHEXYLAMMONIUM SALT
  • BOC-O-BENZYL-L-TRANS-4-HYDROXYPROLINE
  • BOC-O-BENZYL-L-HYDROXYPROLINE
  • BOC-L-HYP(BZL)-OH
  • BOC-HYP(BZL)
  • BOC-HYP(BZL)-OH
  • BOC-HYP(BZL)-OH DCHA
  • BOC-HYDROXYPROLINE(BZL)-OH
  • Boc-O-benzyl-trans-4-hydroxy-L-proline
  • Boc-O-Benzyl-L-Hydroxyproline Dicyclohexylammonium Salt
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-4-O-BENZYL-HYDROXYPROLINE
  • NALPHA-tert-Butoxycarbonyl-O-benzyl-trans-4-hydroxy-L-proline
  • N-alpha-t-Butyloxycarbonyl-4-O-benzyl-trans-L-hydroxyproline
  • (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
  • (Tert-Butoxy)Carbonyl Hyp(Bzl)-OH
  • 1,2-Pyrrolidinedicarboxylic acid, 4-(phenylmethoxy)-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
  • (2S,4R)-4-(Benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicaci
  • BOC-HYP(BZL)-OH USP/EP/BP
  • Boc-Hyp(Bzl)·DCHA
  • (2S,4R)-N-Boc-4-(benzyloxy)pyrrolidine-2-carboxylic Acid
  • 54631-81-1
  • 54631-81-8
  • C29H46N2O5
  • C17H23NO5C12H23N
  • Specialty Synthesis
  • Proline Derivatives
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Hydroxyproline [Hyp]
  • Unusual Amino Acids
  • Boc-Amino acid series
  • Amino Acid Derivatives
  • Amino Acids