H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

Product Name: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
CAS No.: 249537-73-3
Chemical Name: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
Synonyms: VIVIT;NFAT INHIBITOR;MAGPHPVIVITGPHEE;NFAT Inhibitor-1;NFAT INHIBITOR?, >98%;NFAT Inhibitor (VIVIT peptide);NFAT Inhibitor >96% (HPLC), solid;NFAT Inhibitor，VIVIT peptide，MAGPHPVIVITGPHEE;NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%;MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU
CBNumber: CB6148948
Molecular Formula: C75H118N20O22S
Formula Weight: 1683.93
MOL File: 249537-73-3.mol

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H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Property

Boiling point:: 1982.4±65.0 °C(Predicted)
Density: 1.334±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 15 mg/ml; Water: 10 mg/ml
form: solid
pka: 3.12±0.10(Predicted)
color: White to off-white
Water Solubility: Soluble to 2 mg/ml in water
Sequence: H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N7032
Product name: NFAT Inhibitor
Purity: >96% (HPLC), solid
Packaging: 1MG
Price: $613
Updated: 2025/07/31

Sigma-Aldrich

Product number: 480402
Product name: NFAT Inhibitor
Purity: The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Packaging: 500μG
Price: $145
Updated: 2025/07/31

Cayman Chemical

Product number: 13855
Product name: NFAT Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $82
Updated: 2024/03/01

Cayman Chemical

Product number: 13855
Product name: NFAT Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $362
Updated: 2024/03/01

Cayman Chemical

Product number: 13855
Product name: NFAT Inhibitor
Purity: ≥95%
Packaging: 10mg
Price: $642
Updated: 2024/03/01

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H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Chemical Properties,Usage,Production

Description

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).

Uses

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

storage

Store at -20°C

References

[1] JOSE? ARAMBURU. Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A[J]. Science, 1999, 285 5436. DOI: 10.1126/science.285.5436.2129
[2] MICHAEL H A ROEHRL. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 20: 7554-7559. DOI: 10.1073/pnas.0401835101
[3] HAIXIANG YU. Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2006, 26 7: 1531-1537. DOI: 10.1161/01.atv.0000225286.30710.af
[4] XUEQIANG ZHAO. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression[J]. Nature Medicine, 2017, 23 3: 337-346. DOI: 10.1038/nm.4260

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Suppliers

China 97 France 1 Switzerland 1 United Kingdom 2 United States 12 USA 1 Global 114

3B Pharmachem (Wuhan) International Co.,Ltd.

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Sigma-Aldrich

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Creative Peptides

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Shanghai YuanYe Biotechnology Co., Ltd.

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View Lastest Price from H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH manufacturers

Career Henan Chemical Co

Product: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH 249537-73-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

249537-73-3, H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OHRelated Search:

H-GLU-GLU-OH H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Nfat Inhibitor

MAGPHPVIVITGPHEE

MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

NFAT INHIBITOR

VIVIT

NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%

NFAT INHIBITOR?, >98%

NFAT Inhibitor (VIVIT peptide)

L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-

NFAT Inhibitor >96% (HPLC), solid

L-Methionyl-L-Alanylglycyl-L-Prolyl-L-Histidyl-L-Prolyl-L-Valyl-L-Isoleucyl-L-Valyl-L-Isoleucyl-L-Threonylglycyl-L-Prolyl-L-Histidyl-L-alpha-Glutamyl-L-Glutamic Acid

NFAT Inhibitor-1

N-L-Methionyl-L-alanylglycyl-L-prolyl-L-histidyl-N-ethyl-L-alanyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-glutamyl-L-glutamic acid

NFAT Inhibitor，VIVIT peptide，MAGPHPVIVITGPHEE

249537-73-3

C75H118N20O22S

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Gene Regulation and Expression

Gene Regulation

Cell Signaling and Neuroscience

Gene Regulation and Expression