H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

Product Name: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
CAS No.: 249537-73-3
Chemical Name: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
Synonyms: VIVIT;NFAT INHIBITOR;MAGPHPVIVITGPHEE;NFAT Inhibitor-1;NFAT INHIBITOR?, >98%;NFAT Inhibitor (VIVIT peptide);NFAT Inhibitor >96% (HPLC), solid;NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%;MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU;H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
CBNumber: CB6148948
Molecular Formula: C75H118N20O22S
Formula Weight: 1683.93
MOL File: 249537-73-3.mol

More

Less

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Property

Boiling point:: 1982.4±65.0 °C(Predicted)
Density: 1.334±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 15 mg/ml; Water: 10 mg/ml
form: solid
pka: 3.12±0.10(Predicted)
color: White to off-white
Water Solubility: Soluble to 2 mg/ml in water
Sequence: H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2933299090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N7032
Product name: NFAT Inhibitor
Purity: >96% (HPLC), solid
Packaging: 1MG
Price: $595
Updated: 2024/03/01

Sigma-Aldrich

Product number: 480402
Product name: NFAT Inhibitor
Purity: The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Packaging: 500μG
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 13855
Product name: NFAT Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $82
Updated: 2024/03/01

Cayman Chemical

Product number: 13855
Product name: NFAT Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $362
Updated: 2024/03/01

Cayman Chemical

Product number: 13855
Product name: NFAT Inhibitor
Purity: ≥95%
Packaging: 10mg
Price: $642
Updated: 2024/03/01

More

Less

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Chemical Properties,Usage,Production

Description

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).

Uses

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

storage

Store at -20°C

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Suppliers

China 75 France 1 Switzerland 1 United Kingdom 2 United States 12 USA 1 Global 92

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Hangzhou Peptide Biochem Co.,Ltd

Tel: 0571-89197072; 18668118770
Fax: 0571-89197072
Email: linda@peptide-china.com
Country: China
ProdList: 248
Advantage: 56

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

More

Less

View Lastest Price from H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH manufacturers

Career Henan Chemical Co

Product: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH 249537-73-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

249537-73-3, H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OHRelated Search:

H-GLU-GLU-OH H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Nfat Inhibitor

MAGPHPVIVITGPHEE

MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

NFAT INHIBITOR

VIVIT

NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%

NFAT INHIBITOR?, >98%

NFAT Inhibitor (VIVIT peptide)

L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-

NFAT Inhibitor >96% (HPLC), solid

L-Methionyl-L-Alanylglycyl-L-Prolyl-L-Histidyl-L-Prolyl-L-Valyl-L-Isoleucyl-L-Valyl-L-Isoleucyl-L-Threonylglycyl-L-Prolyl-L-Histidyl-L-alpha-Glutamyl-L-Glutamic Acid

NFAT Inhibitor-1

249537-73-3

C75H118N20O22S

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Gene Regulation and Expression

Gene Regulation

Cell Signaling and Neuroscience

Gene Regulation and Expression