2-BENZYLOXY-5-BROMO-BENZOIC ACID
- Product Name
- 2-BENZYLOXY-5-BROMO-BENZOIC ACID
- CAS No.
- 62176-31-2
- Chemical Name
- 2-BENZYLOXY-5-BROMO-BENZOIC ACID
- Synonyms
- Albb-008969;5-bromo-2-(phenylmethoxy)benzoic acid;Benzoic acid, 5-bromo-2-(phenylmethoxy)-
- CBNumber
- CB61489712
- Molecular Formula
- C14H11BrO3
- Formula Weight
- 307.14
- MOL File
- 62176-31-2.mol
2-BENZYLOXY-5-BROMO-BENZOIC ACID Property
- Melting point:
- 106.1-107.4 °C
- Boiling point:
- 442.2±35.0 °C(Predicted)
- Density
- 1.514±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.09±0.36(Predicted)
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B291418
- Product name
- 2-Benzyloxy-5-bromobenzoicacid
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FB119040
- Product name
- 2-(Benzyloxy)-5-bromobenzoic acid
- Packaging
- 250mg
- Price
- $57.5
- Updated
- 2021/12/16
- Product number
- V6937
- Product name
- 2-Benzyloxy-5-bromobenzoicacid
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- FB119040
- Product name
- 2-(Benzyloxy)-5-bromobenzoic acid
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 040003
- Product name
- 2-(Benzyloxy)-5-bromobenzoic acid
- Packaging
- 500mg
- Price
- $126
- Updated
- 2021/12/16
2-BENZYLOXY-5-BROMO-BENZOIC ACID Chemical Properties,Usage,Production
Synthesis
850350-09-3
62176-31-2
Benzyl 2-benzyloxy-5-bromobenzoate (18 g, 45.3 mmol) was used as starting material and dissolved in methanol (50 mL). Subsequently, a solution of sodium hydroxide (7.25 g, 181 mmol) in water (20.00 mL) was added to this solution. The reaction mixture was heated to 60°C and the reaction was stirred at this temperature for 2 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation. The residue was diluted with water and washed with ethyl acetate (EA). The aqueous layer was separated and acidified to pH=3 with 4N hydrochloric acid solution and subsequently extracted with ethyl acetate (EA). The organic phases were combined, washed sequentially with water and saturated brine and dried over anhydrous sodium sulfate. Finally, the target product 2-(benzyloxy)-5-bromobenzoic acid (13.46 g, 97% yield) was obtained by concentration under reduced pressure.LCMS analysis showed [M+H]+ m/z 307,309.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2019, vol. 29, # 2, p. 212 - 215
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 17, p. 4034 - 4038
[3] Patent: WO2011/38572, 2011, A1. Location in patent: Page/Page column 50
2-BENZYLOXY-5-BROMO-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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