TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- Product Name
- TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- CAS No.
- 259809-79-5
- Chemical Name
- TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
- Synonyms
- tert-butyl 7;pyrido[4,3-d]pyrimidine-6(5H);8-dihydro-2-(Methylsulfonyl)pyrido[4;tert-Butyl 7,8-dihydro-2-(methylsulfonyl);6-Boc-2-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine;tert-butyl 2-Methanesulfonyl-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-6-carboxylate;TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE;2-methylsulfonyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert-butyl ester;2-Methanesulfonyl-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine -6-carboxylic acid tert-butyl ester;Pyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid, 7,8-dihydro-2-(methylsulfonyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB61502046
- Molecular Formula
- C13H19N3O4S
- Formula Weight
- 313.37
- MOL File
- 259809-79-5.mol
TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Property
- Boiling point:
- 495.6±55.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.86±0.20(Predicted)
- Appearance
- White to off-white Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB148747
- Product name
- tert-Butyl7,8-dihydro-2-(methylsulfonyl)pyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 25mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- FB148747
- Product name
- tert-Butyl7,8-dihydro-2-(methylsulfonyl)pyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 50mg
- Price
- $159
- Updated
- 2021/12/16
- Product number
- W4935
- Product name
- tert-Butyl7,8-dihydro-2-(methylsulfonyl)pyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 1g
- Price
- $489
- Updated
- 2021/12/16
- Product number
- CHM0385400
- Product name
- TERT-BUTYL-7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6-(5H)-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.05
- Updated
- 2021/12/16
- Product number
- FB148747
- Product name
- tert-Butyl7,8-dihydro-2-(methylsulfonyl)pyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- Packaging
- 250mg
- Price
- $552.5
- Updated
- 2021/12/16
TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
259809-78-4
259809-79-5
Method I - Step c: Synthesis of tert-butyl 2-(methylsulfonyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate [2-12]. Tert-butyl 2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (7.38 g, 26.26 mmol) was dissolved in 50 mL of dichloromethane, and 3-chloroperoxybenzoic acid (75%, 12.5 g, 54.50 mmol) was slowly added at 0 °C. The reaction mixture was stirred at room temperature for 12 hours. Subsequently, saturated sodium bicarbonate solution (10 mL) and saturated sodium thiosulfate solution (10 mL) were added and stirring was continued for 2 hours at room temperature. The organic layer was separated and concentrated under reduced pressure. Purification by silica gel column chromatography (petroleum ether: ethyl acetate = 3:1) afforded a white solid product (5.5 g, 66.9% yield).1H NMR (400 MHz, CDCl3) δ 8.63 (s, 1H), 4.70 (s, 2H), 3.79 (t, J = 5.9 Hz, 2H), 3.33 (s, 3H), 3.09 (t, J = 5.8 Hz, 2H). 5.8 Hz, 2H), 1.49 (s, 9H).
References
[1] Patent: WO2014/113191, 2014, A1. Location in patent: Paragraph 0161; 0162
[2] Patent: US2012/71461, 2012, A1. Location in patent: Page/Page column 136
[3] ACS Chemical Neuroscience, 2017, vol. 8, # 9, p. 1980 - 1994
TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 7,8-DIHYDRO-2-(METHYLSULFONYL)PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Suppliers
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 0532-0532-88191853 13061484198
- Fax
- +86-532-88191853
- sales@carelongchem.com
- Country
- China
- ProdList
- 439
- Advantage
- 57
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- +86-18068513926
- Fax
- 0086-519-85153711
- Country
- China
- ProdList
- 1277
- Advantage
- 55
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 18957373295
- Fax
- -
- Country
- China
- ProdList
- 1580
- Advantage
- 58
- Tel
- 0513-0513-51005092 13390947892
- Fax
- 0513-51005092
- tashiyxy@163.com
- Country
- China
- ProdList
- 838
- Advantage
- 58
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
- Tel
- 0574-87487840-805 15888368997
- Fax
- 0574-87485342
- Country
- China
- ProdList
- 474
- Advantage
- 55