4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID
- Product Name
- 4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID
- CAS No.
- 1029721-02-5
- Chemical Name
- 4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID
- Synonyms
- 4-oxo-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-2-carboxylic acid;4,5,6,7-tetrahydro-4-oxo-Pyrazolo[1,5-a]pyrazine-2-carboxylic acid;4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID;Pyrazolo[1,5-a]pyrazine-2-carboxylic acid, 4,5,6,7-tetrahydro-4-oxo-
- CBNumber
- CB61517473
- Molecular Formula
- C7H7N3O3
- Formula Weight
- 181.15
- MOL File
- 1029721-02-5.mol
4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID Property
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E589133
- Product name
- 4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylicAcid
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 3839AQ
- Product name
- 4-Oxo-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrazine-2-CarboxylicAcid
- Packaging
- 1g
- Price
- $615.2
- Updated
- 2021/12/16
- Product number
- CHM0386063
- Product name
- 4,5,6,7-TETRAHYDRO-4-OXO-PYRAZOLO-[1,5-A]PYRAZINE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.87
- Updated
- 2021/12/16
- Product number
- BB-4058292
- Product name
- 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylicacid
- Purity
- 95%
- Packaging
- 5G
- Price
- $595
- Updated
- 2021/12/16
- Product number
- 1029721025
- Product name
- 4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylicacid
- Packaging
- 1g
- Price
- $598.41
- Updated
- 2021/12/16
4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
951626-95-2
1029721-02-5
The general procedure for the synthesis of 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid using ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid as a starting material was as follows: firstly, a solution of lithium hydroxide monohydrate (2.73 g, 65.0 mmol) was prepared by dissolving the lithium hydroxide monohydrate (2.73 g, 65.0 mmol) in water (30.0 mL). Subsequently, this lithium hydroxide aqueous solution was added to a suspension of ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (2.72 g, 13.0 mmol) in tetrahydrofuran (THF, 30 mL) and methanol (MeOH, 30 mL), and the reaction was carried out at 0 °C. Next, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water (20 mL) was added to the residue to dissolve the solid to obtain a clarified solution. This solution was cooled to 0 °C and concentrated. Then, hydrochloric acid (5.42 mL, 65.0 mmol) was slowly added to adjust the pH to 3, at which point solids were precipitated. The suspension was continued to be stirred at 0 °C for 2 h to promote crystallization. Finally, the white solid product was collected by filtration and dried to afford the target compound 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid (2.2 g, 93% yield). The structure of the product was confirmed by LC-MS (ESI), m/z: 182.1 [M + H]+.
References
[1] Patent: WO2016/10950, 2016, A1. Location in patent: Page/Page column 239; 240
4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A] PYRAZINE-2-CARBOXYLIC ACID manufacturers
- Product
- 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid 1029721-02-5
- Price
- US $1.00/GK
- Min. Order
- 1g
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-07