CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID

Product Name: CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID
CAS No.: 110347-85-8
Chemical Name: CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID
Synonyms: Selfotel;CGS 19755;CPDD 0027;LY-272541;Valine Impurity 11;Argatroban Impurity 122;CGS-19755 \ POTENT COMPETITIVE NMDA RECE;4-(phosphonomethyl)-2-piperidinecarboxylic acid;cis-4-[Phosphomethyl]-piperidine-2-carboxylicacid;CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID
CBNumber: CB6154963
Molecular Formula: C7H14NO5P
Formula Weight: 223.16
MOL File: 110347-85-8.mol

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CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID Property

Melting point:: 290-292 °C
Boiling point:: 508.6±60.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: H₂O: soluble
form: solid
pka: 2.29±0.10(Predicted)
color: white
Water Solubility: Soluble to 25 mM in water

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1241
Product name: CGS19755
Packaging: 50
Price: $685
Updated: 2021/12/16

Tocris

Product number: 1241
Product name: CGS19755
Packaging: 10
Price: $163
Updated: 2021/12/16

Usbiological

Product number: 254949
Product name: CGS 19755
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: C291808
Product name: CGS19755
Packaging: 100mg
Price: $1470
Updated: 2021/12/16

ApexBio Technology

Product number: B6652
Product name: CGS19755
Packaging: 10mg
Price: $314
Updated: 2021/12/16

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CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

CGS 19755 is a potent and competitive NMDA antagonist.

Definition

ChEBI: Selfotel is a non-proteinogenic alpha-amino acid.

Biological Activity

Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™ .

in vivo

Selfotel (CGS 19755) administered p.o. by gavage has little or no effect in these test procedures. In an experimental model of anxiety in rats^[1].
Selfotel (CGS 19755) significantly increases conflict responding within a relatively narrow dose range (minimum effective dose, 1.73 mg/kg i.p.)^[1].
Selfotel (CGS 19755) blocks the harmaline-induced increase in cerebellar cyclic GMP levels at a dose of 4 mg/kg i.p. with duration of action exceeding 2 hr^[2].
Selfotel (CGS 19755) inhibits convulsions elicited by maximal electroshock in rat (ED₅₀ = 3.8 mg/kg i.p. 1 hr after administration) and in mouse (ED₅₀ = 2.0 mg/kg i.p. 0.5 hr after administration)^[2].

storage

Store at RT

CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID Suppliers

China 39 Europe 1 Germany 2 Switzerland 1 United Kingdom 4 United States 7 USA 1 Global 55

3B Pharmachem (Wuhan) International Co.,Ltd.

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Labnetwork lnc.

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110347-85-8, CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACIDRelated Search:

4-AMINOBUTYLPHOSPHONIC ACID L-AP5 5-PHOSPHONOPENTANOIC ACID DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID

4-(phosphonomethyl)-2-piperidinecarboxylic acid

CGS 19755

CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID

Selfotel

CGS-19755 \ POTENT COMPETITIVE NMDA RECE

cis-4-[Phosphomethyl]-piperidine-2-carboxylicacid

LY-272541

CPDD 0027

CIS-(2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid

2-Piperidinecarboxylic acid, 4-(phosphonomethyl)-, (2R,4S)-rel-

(2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid

CGS19755,CGS-19755,iGluR,Selfotel,Ionotropic glutamate receptors,Inhibitor,inhibit

Argatroban Impurity 122

Valine Impurity 11

110347-85-8

Glutamate receptor