(5-bromo-2-nitrophenyl)methanol
- Product Name
- (5-bromo-2-nitrophenyl)methanol
- CAS No.
- 1241894-37-0
- Chemical Name
- (5-bromo-2-nitrophenyl)methanol
- Synonyms
- 5-Bromo-2-nitrobenzylalcohol;2-Nitro-5-bromobenzyl Alcohol;(5-bromo-2-nitrophenyl)methanol;5-Bromo-2-nitrobenzylic alcohol;Benzenemethanol, 5-bromo-2-nitro-;(5-Bromo-2-nitrophenyl)methanol - [B90097]
- CBNumber
- CB61554106
- Molecular Formula
- C7H6BrNO3
- Formula Weight
- 232.03
- MOL File
- 1241894-37-0.mol
(5-bromo-2-nitrophenyl)methanol Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- wooly crystalline solid
- color
- Cream (hint of peach)
Safety
- HS Code
- 2909498090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B698038
- Product name
- (5-Bromo-2-nitrophenyl)methanol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR400635
- Product name
- 5-Bromo-2-nitrobenzylalcohol
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 4654-9-80
- Product name
- 5-Bromo-2-nitrobenzyl alcohol
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- Z8745
- Product name
- (5-Bromo-2-nitrophenyl)methanol
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- OR400635
- Product name
- 5-Bromo-2-nitrobenzylalcohol
- Packaging
- 5g
- Price
- $186
- Updated
- 2021/12/16
(5-bromo-2-nitrophenyl)methanol Chemical Properties,Usage,Production
Synthesis
6950-43-2
1241894-37-0
General procedure for the synthesis of (5-bromo-2-nitrophenyl)methanol from 5-bromo-2-nitrobenzoic acid: to a solution of 5-bromo-2-nitrobenzoic acid (280 g, 1.14 mol, 1.0 eq.) in tetrahydrofuran (THF, 1.5 L) was slowly added dropwise a THF solution of 10 M borane-dimethyl sulfide (BH3-Me2S) (119.7 mL, 1.05 equivalent) for 30 min. After dropwise addition, the reaction mixture was heated to 70 °C and maintained at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and methanol (MeOH, 100 mL) was slowly added to quench the reaction, followed by concentration under reduced pressure. To the concentrated residue was added a mixed petroleum ether/ethyl acetate solvent (1000 mL, 10:1 volume ratio) and stirred for 1 hour. The precipitate precipitated was collected by filtration to afford the target product (5-bromo-2-nitrophenyl)methanol (160 g, 689 mmol, 60.49% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, chloroform-d): δ=7.98-7.91 (m, 2H), 7.55 (dd, J=1.8,8.8 Hz, 1H), 4.97 (br.s., 2H), 2.77 (br.s., 1H). The mass spectrum (ESI) showed [M+H]+ peaks of 232.2/234.2.
References
[1] Patent: WO2018/68017, 2018, A1. Location in patent: Page/Page column 154; 156; 157
[2] Patent: US2017/190713, 2017, A1. Location in patent: Paragraph 0189
[3] Chemistry - A European Journal, 2012, vol. 18, # 12, p. 3706 - 3720
[4] Small, 2015, vol. 11, # 33, p. 4090 - 4096
(5-bromo-2-nitrophenyl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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