2-(2-bromo-5-methoxyphenyl)ethanol
- Product Name
- 2-(2-bromo-5-methoxyphenyl)ethanol
- CAS No.
- 75534-35-9
- Chemical Name
- 2-(2-bromo-5-methoxyphenyl)ethanol
- Synonyms
- 2-(2-bromo-5-methoxyphenyl)ethanol;Benzeneethanol, 2-bromo-5-methoxy-;2-(2-Bromo-5-methoxyphenyl)ethan-1-ol
- CBNumber
- CB61556812
- Molecular Formula
- C9H11BrO2
- Formula Weight
- 231.09
- MOL File
- 75534-35-9.mol
2-(2-bromo-5-methoxyphenyl)ethanol Property
- Boiling point:
- 314.8±27.0 °C(Predicted)
- Density
- 1.444±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.73±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B711268
- Product name
- 2-(2-Bromo-5-methoxyphenyl)ethanol
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 1737AC
- Product name
- 2-(2-Bromo-5-methoxyphenyl)ethanol
- Packaging
- 100mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- HCH0050378
- Product name
- 2-(2-BROMO-5-METHOXYPHENYL)ETHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.19
- Updated
- 2021/12/16
- Product number
- A135798
- Product name
- 2-(2-Bromo-5-methoxyphenyl)ethanol
- Purity
- 97%
- Packaging
- 100mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- A135798
- Product name
- 2-(2-Bromo-5-methoxyphenyl)ethanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $59
- Updated
- 2021/12/16
2-(2-bromo-5-methoxyphenyl)ethanol Chemical Properties,Usage,Production
Synthesis
5020-41-7
75534-35-9
General procedure for the synthesis of 2-(2-bromo-5-methoxyphenyl)ethanol from 2-(3-methoxyphenyl)ethanol: (i) 3-methoxyphenylethanol (1.18 g, 7.8 mmol) and pyridine (0.75 mL, 9.3 mmol) were dissolved in anhydrous dichloromethane (10 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, bromine (0.47 mL, 18.0 mmol) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 4 h. The solution was orange in color. Upon completion of the reaction, the reaction was quenched by the addition of 10% aqueous sodium bisulfite and extracted with dichloromethane. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography with gradient elution using hexane and ethyl acetate (10:1, 8:1, 5:1) as eluents to afford the target compound 2-(2-bromo-5-methoxyphenyl)ethanol as a colorless oil (1.5 g, 83.2% yield).1H-NMR (CDCl3) data: δ 7.43 (d, J = 8.8 Hz, 1H) , 6.83 (d, J = 3.3 Hz, 1H), 6.67 (dd, J = 8.8, 3.3 Hz, 1H), 3.91-3.81 (m, 2H), 3.78 (s, 3H), 2.99 (t, J = 6.6 Hz, 2H).
References
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 15, p. 7193 - 7205
[2] Patent: EP2963027, 2016, A1. Location in patent: Paragraph 0102; 0103; 0104
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 15, p. 7399 - 7409
[4] Journal of Organic Chemistry, 1981, vol. 46, # 1, p. 118 - 122
[5] Patent: US6239147, 2001, B1
2-(2-bromo-5-methoxyphenyl)ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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