ChemicalBook > CAS DataBase List > 3-amino-1H-indazole-6-carboxylic acid
3-amino-1H-indazole-6-carboxylic acid
- Product Name
- 3-amino-1H-indazole-6-carboxylic acid
- CAS No.
- 871709-92-1
- Chemical Name
- 3-amino-1H-indazole-6-carboxylic acid
- Synonyms
- 3-amino-1H-indazole-6-carboxylic acid;3-amino-2H-indazole-6-carboxylic acid;1H-Indazole-6-carboxylic acid, 3-amino-
- CBNumber
- CB61558694
- Molecular Formula
- C8H7N3O2
- Formula Weight
- 177.16
- MOL File
- 871709-92-1.mol
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3-amino-1H-indazole-6-carboxylic acid Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Red to reddish brown Solid
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N-Bromosuccinimide Price
Biosynth Carbosynth
- Product number
- FA141446
- Product name
- 3-Amino-1H-indazole-6-carboxylic acid
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA141446
- Product name
- 3-Amino-1H-indazole-6-carboxylic acid
- Packaging
- 100mg
- Price
- $113
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA141446
- Product name
- 3-Amino-1H-indazole-6-carboxylic acid
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
AK Scientific
- Product number
- Z5229
- Product name
- 3-Amino-1H-indazole-6-carboxylicacid
- Packaging
- 250mg
- Price
- $353
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA141446
- Product name
- 3-Amino-1H-indazole-6-carboxylic acid
- Packaging
- 500mg
- Price
- $390
- Updated
- 2021/12/16
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3-amino-1H-indazole-6-carboxylic acid Chemical Properties,Usage,Production
Synthesis
176508-81-9
871709-92-1
General procedure for the synthesis of 3-amino-1H-indazole-6-carboxylic acid from 4-cyano-3-fluorobenzoic acid: 4-cyano-3-fluorobenzoic acid (500 mg, 3.0 mmol) was dissolved in n-butanol (9 mL), followed by the addition of hydrazine monohydrate (0.5 mL, 10 mmol). The reaction mixture was heated to 110 °C and the reaction was stirred at this temperature overnight. Upon completion of the reaction, the mixture was cooled to room temperature and the precipitate precipitated was collected by filtration. The resulting solid was dissolved in 1 N aqueous sodium hydroxide (2 mL) and extracted with ethyl acetate (2 x 2 mL) to remove organic impurities. Subsequently, the aqueous phase was acidified with 1 N aqueous hydrochloric acid to pH=4, at which point the target product began to precipitate. The precipitate was collected by filtration and dried under vacuum to yield 3-amino-1H-indazole-6-carboxylic acid (140 mg, 26% yield) as a red solid. The product was confirmed by ESI mass spectrum (M+H+ m/z 178.2) and further characterized by 1H NMR (400 MHz, CD3OD): δ 7.99-8.01 (m, 1H), 7.73 (dd, J = 8.4, 0.8 Hz, 1H), 7.61 (dd, J = 8.5, 1.3 Hz, 1H).
References
[1] Patent: US2012/108619, 2012, A1. Location in patent: Page/Page column 33
3-amino-1H-indazole-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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