(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride
- Product Name
- (R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride
- CAS No.
- 1004538-34-4
- Chemical Name
- (R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride
- Synonyms
- (R)-3-AMINO-1-N-BOC-PYRROLIDINE-HCl;(R)-1-Boc-3-amino-pyrrolidine hydrochloride;(R)-TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE HCL;3-amino-1-pyrrolidinecarboxylic acid tert-butyl ester;(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride;(3R)-3-Aminopyrrolidine-1-carboxylic acid tert-butyl ester HCl;3-Amino-1-pyrrolidinecarboxylic acid tert-butyl ester hydrochloride;(R)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine hydrochloric acid salt;(3R)-3-amino-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride (1:1);1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, hydrochloride (1:1), (3R)-
- CBNumber
- CB61570588
- Molecular Formula
- C9H19ClN2O2
- Formula Weight
- 222.71236
- MOL File
- 1004538-34-4.mol
(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y6628
- Product name
- (R)-tert-Butyl3-aminopyrrolidine-1-carboxylatehydrochloride
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- AS16253
- Product name
- 1-Boc-(R)-3-aminopyrrolidine HCl
- Purity
- 97+% ee
- Packaging
- 5G
- Price
- $71
- Updated
- 2021/12/16
- Product number
- AS16253
- Product name
- 1-Boc-(R)-3-aminopyrrolidine HCl
- Purity
- 97+% ee
- Packaging
- 25g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- CCH0005271
- Product name
- (R)-3-AMINO-1-N-BOC-PYRROLIDINE-HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $421.05
- Updated
- 2021/12/16
- Product number
- AS16253
- Product name
- 1-Boc-(R)-3-aminopyrrolidine HCl
- Purity
- 97+% ee
- Packaging
- 100g
- Price
- $526
- Updated
- 2021/12/16
(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride Chemical Properties,Usage,Production
Synthesis
147081-49-0
1004538-34-4
Step 10-3: Preparation of (R)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine hydrochloride: according to the method described in Step 10-1, 2.60 g of (R)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine (chemical purity: 48.7 area %, optical purity: 96.6% ee, relative to the (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester hydrochloride HPLC area value, containing 48.4% optically active 1-(tert-butoxycarbonyl)-3-methoxypyrrolidine (represented by formula (9)) and 31.9% 1-(tert-butoxycarbonyl)-3,4-dehydropyrrolidine (represented by formula (10)) was dissolved in 30 mL of isopropanol. To this solution was added 1.39 g of concentrated hydrochloric acid followed by concentration under reduced pressure. To the concentrate was added 50 mL of ethyl acetate and stirred at 22°C for 30 minutes. After continued stirring for 30 minutes under ice bath cooling, the crystals were collected by filtration under reduced pressure. The crystals were washed with 20 mL of ethyl acetate and subsequently dried under vacuum to afford 2.51 g of white solid (R)-tert-butyl (R)-3-aminopyrrolidine-1-carboxylate hydrochloride (chemical purity: 99.6 area %, yield: 95%, optical purity: 99.7% ee). It was confirmed by HPLC analysis that optically active 1-(tert-butoxycarbonyl)-3-methoxypyrrolidine represented by formula (9) and 1-(tert-butoxycarbonyl)-3,4-dehydropyrrolidine represented by formula (10) were not detected.
References
[1] Patent: EP2050735, 2009, A1. Location in patent: Page/Page column 22
(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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