1,3-difluoro-2-methyl-4-nitrobenzene
- Product Name
- 1,3-difluoro-2-methyl-4-nitrobenzene
- CAS No.
- 79562-49-5
- Chemical Name
- 1,3-difluoro-2-methyl-4-nitrobenzene
- Synonyms
- 2,6-Difluoro-3-nitrotoluene;2,6-Difluoro-3-nitrotoluene,98%;1,3-difluoro-2-methyl-4-nitrobenzene;Benzene, 1,3-difluoro-2-methyl-4-nitro-
- CBNumber
- CB61570720
- Molecular Formula
- C7H5F2NO2
- Formula Weight
- 173.12
- MOL File
- 79562-49-5.mol
1,3-difluoro-2-methyl-4-nitrobenzene Property
- Boiling point:
- 237.2±35.0 °C(Predicted)
- Density
- 1.374±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- Appearance
- White to off-white Solid
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H5F2NO2/c1-4-5(8)2-3-6(7(4)9)10(11)12/h2-3H,1H3
- InChIKey
- AVWNNVJXXMKAPB-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C([N+]([O-])=O)C(F)=C1C
Safety
- RIDADR
- UN2811
- HazardClass
- 6.1
- HS Code
- 2902900000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D456793
- Product name
- 1,3-difluoro-2-methyl-4-nitrobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC400731
- Product name
- 2,6-Difluoro-3-nitrotoluene
- Purity
- 97%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 4754-3-05
- Product name
- 1,3-Difluoro-2-methyl-4-nitrobenzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- PC400731
- Product name
- 2,6-Difluoro-3-nitrotoluene
- Purity
- 97%
- Packaging
- 5g
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 4754-3-05
- Product name
- 1,3-Difluoro-2-methyl-4-nitrobenzene
- Purity
- 97%
- Packaging
- 5G
- Price
- $172
- Updated
- 2021/12/16
1,3-difluoro-2-methyl-4-nitrobenzene Chemical Properties,Usage,Production
Uses
2,6-Difluoro-3-nitrotoluene used as a intermediate in organic synthesis, pharmaceutical and chemical research.
Synthesis
443-84-5
79562-49-5
Example A36: 65% HNO3 (11.4 g, 0.12 mol) was slowly added dropwise to a solution of 1,3-difluoro-2-methylbenzene (15 g, 0.12 mol) dissolved in H2SO4 (100 mL) at -10°C. The reaction mixture was stirred continuously at this temperature for 30 minutes. Upon completion of the reaction, the mixture was carefully poured into ice water and subsequently extracted with EtOAc (3 x 200 mL). The combined organic phases were washed with saturated brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the target product 1,3-difluoro-2-methyl-4-nitrobenzene (16 g, 78% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.80 (m, 1H), 6.8-7.1 (m, 1H), 2.30 (s, 3H).
References
[1] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 10, p. 3530 - 3543
[2] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 40
[3] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 64
[4] Patent: WO2013/36232, 2013, A2. Location in patent: Paragraph 00273
[5] Patent: US2014/315917, 2014, A1. Location in patent: Paragraph 0506
1,3-difluoro-2-methyl-4-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-difluoro-2-methyl-4-nitrobenzene manufacturers
- Product
- 1,3-difluoro-2-methyl-4-nitrobenzene 79562-49-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 100kg/week
- Release date
- 2019-08-05