ChemicalBook > CAS DataBase List > 5-CHLORO-2-METHYLPHENYLBORONIC ACID

5-CHLORO-2-METHYLPHENYLBORONIC ACID

Product Name
5-CHLORO-2-METHYLPHENYLBORONIC ACID
CAS No.
148839-33-2
Chemical Name
5-CHLORO-2-METHYLPHENYLBORONIC ACID
Synonyms
5-CHLORO-2-METHYLPHE;5-Chloro-o-tolylboronic Acid;5-Chloro-2-methylphenylboronicaci;2-METHYL-5-CHLOROPHENYLBORONICACID;5-CHLORO-2-METHYLPHENYLBORONIC ACID;5-Chloro-2-Methylphenyl boconic acid;5-CHLORO-2-METHYLBENZENEBORONIC ACID;5-Chloro-2-methylphenyl boronic acid ,97%;Boronic acid, B-(5-chloro-2-methylphenyl)-;5-Chloro-2-methylphenylboronic acid - [C2230]
CBNumber
CB6161657
Molecular Formula
C7H8BClO2
Formula Weight
170.4
MOL File
148839-33-2.mol
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5-CHLORO-2-METHYLPHENYLBORONIC ACID Property

Melting point:
162-166
Boiling point:
328.0±52.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
7.63±0.58(Predicted)
color 
White to Almost white
CAS DataBase Reference
148839-33-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22-36-22
Safety Statements 
26-36/37/39-36-60-37
Hazard Note 
Irritant
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2665
Product name
5-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
C2665
Product name
5-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$155
Updated
2025/07/31
TRC
Product number
C587468
Product name
5-Chloro-2-methylphenylboronicacid
Packaging
1g
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-W000875
Product name
(5-Chloro-2-methylphenyl)boronicacid
Purity
99.64%
Packaging
25g
Price
$77
Updated
2021/12/16
Chem-Impex
Product number
40311
Product name
5-Chloro-2-methylphenylboronicacid,97-105%(Assaybytitration)
Purity
97-105%(Assaybytitration)
Packaging
1G
Price
$38.08
Updated
2021/12/16
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5-CHLORO-2-METHYLPHENYLBORONIC ACID Chemical Properties,Usage,Production

Chemical Properties

Off-white Cryst

Uses

suzuki reaction

Synthesis

121-43-7

33184-48-4

148839-33-2

The general procedure for the synthesis of 5-chloro-2-methylphenylboronic acid from trimethyl borate and 4-chloro-2-iodotoluene was carried out as follows: firstly, magnesium shavings (0.346 g, 14.25 mmol) were activated by heating in an oven at 120°C for 16 hours. Anhydrous tetrahydrofuran (50 ml) and a small amount of iodine crystals were added to the activated magnesium crumbs using pre-oven dried glassware. Subsequently, 4-chloro-2-iodotoluene was added via syringe and the reaction system was ensured to be in an oxygen-free environment. The reaction mixture was heated and refluxed for 5.5 hours under a continuous flow of argon gas. Upon completion of the reaction, the system was cooled to -78°C (using a dry ice-acetone bath) and a solution of anhydrous tetrahydrofuran (10 ml) of trimethyl borate (2.47 g, 23.76 mmol) was slowly added dropwise. After the dropwise addition, the reaction system was allowed to warm up slowly to room temperature and stirring was continued for 16 hours. At the end of the reaction, the reaction was quenched by careful addition of 1 M hydrochloric acid (20 ml), followed by extraction of the reaction mixture with ether (3 x 50 ml). The organic phases were combined, washed with water (3 x 50 ml), dried with magnesium sulfate and concentrated under reduced pressure. Finally, the residue was washed with hexane to afford the target product 5-chloro-2-methylphenylboronic acid (0.537 g, 26% yield) as a white powder.

References

[1] Patent: US2004/204386, 2004, A1

5-CHLORO-2-METHYLPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-2-METHYLPHENYLBORONIC ACID Suppliers

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View Lastest Price from 5-CHLORO-2-METHYLPHENYLBORONIC ACID manufacturers

Career Henan Chemical Co
Product
5-CHLORO-2-METHYLPHENYLBORONIC ACID 148839-33-2
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg;5kg;100kg
Release date
2019-07-04

148839-33-2, 5-CHLORO-2-METHYLPHENYLBORONIC ACIDRelated Search:

5-Chloro-2-formylphenylboronic acid 2-BORONO-4-CHLOROBENZOIC ACID 5-CHLORO-2-(ETHOXYCARBONYL)PHENYLBORONIC ACID 5-CHLORO-2-METHYLPHENYLBORONIC ACID 2-Bromo-6-chloro-3-methylphenylboronic acid 3-CHLORO-5-METHYLPHENYLBORONIC ACID 6-Bromo-2-chloro-3-methylphenylboronic acid 3-CHLORO-2-METHYLPHENYLBORONIC ACID 2-Chloro-5-methylphenylboronic acid 96%,2-Chloro-5-methylphenylboronic acid ,98%,2-CHLORO-5-METHYLPHENYLBORONIC ACID 4-CHLORO-2-METHYLPHENYLBORONIC ACID,4-Chloro-2-methylphenylboronic acid ,98% 4-CHLORO-3-METHYLPHENYLBORONIC ACID 3-CHLORO-4-METHYLPHENYLBORONIC ACID,3-CHLORO-4-METHYLPHENYLBORONIC ACID 96% 2-Chloro-4-methylphenylboronic acid 5-CHLORO-2-CYANOPHENYLBORONIC ACID NEOPENTYL GLYCOL ESTER (5-CHLORO-2-[(2,2-DIMETHYLPROPOXY)CARBONYL]PHENYL)BORONIC ACID 3,5-Dichloro-2-methylphenylboronic acid 5-Chloro-2-(methoxycarbonyl)phenylboronic acid T-BUTYL-4'-CHLOROBENZOATE-2'-BORONIC ACID

  • 5-CHLORO-2-METHYLPHENYLBORONIC ACID
  • 5-CHLORO-2-METHYLBENZENEBORONIC ACID
  • 2-METHYL-5-CHLOROPHENYLBORONICACID
  • 5-Chloro-2-methylphenyl boronic acid ,97%
  • 5-CHLORO-2-METHYLPHE
  • 5-Chloro-2-Methylphenylboronic Acid (contains varying aMounts of Anhydride)
  • 5-Chloro-2-Methylphenyl boconic acid
  • Boronic acid, B-(5-chloro-2-methylphenyl)-
  • 5-Chloro-2-methylphenylboronicaci
  • 5-Chloro-o-tolylboronic Acid
  • 5-Chloro-2-methylphenylboronic acid - [C2230]
  • 148839-33-2
  • 148839332
  • C9H7BClO2
  • blocks
  • BoronicAcids
  • Substituted Boronic Acids
  • Aryl
  • Boronic acid
  • Organoborons