2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL
- Product Name
- 2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL
- CAS No.
- 1942-71-8
- Chemical Name
- 2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL
- Synonyms
- propargite metab.;2-(p-t-butylphenoxy)cyclohexanol;2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL;2-(p-tert-butylphenoxy)-cyclohexano;CYCLOHEXANOL-2-(4-TERT-BUTYL-PHENOXY);2-(4-tert-butylphenoxy)cyclohexan-1-ol;2-(4-tert-butylphenoxy)-1-cyclohexanol;2-[4-(1,1-DIMETHYLETHYL)PHENOXY]CYCLOHEXANOL;C11825000 Cyclohexanol-2-(4-tert-butyl-phenox;Cyclohexanol, 2-[4-(1,1-dimethylethyl)phenoxy]-
- CBNumber
- CB6174651
- Molecular Formula
- C16H24O2
- Formula Weight
- 248.36
- MOL File
- 1942-71-8.mol
2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL Property
- Melting point:
- 93-95 °C
- Boiling point:
- 365.7±42.0 °C(Predicted)
- Density
- 1.036±0.06 g/cm3(Predicted)
- storage temp.
- Store at 4℃
- solubility
- 24.84mg/ml in DMSO, 24.84mg/ml in Ethanol
- form
- powder
- pka
- 14.60±0.40(Predicted)
- color
- white to beige
- EPA Substance Registry System
- 2-(p-tert-Butylphenoxy)cyclohexanol (1942-71-8)
Safety
- Hazardous Substances Data
- 1942-71-8(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- CHM0078071
- Product name
- 2-(4-TERT-BUTYLPHENOXY) CYCLOHEXANOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- CHM0078071
- Product name
- 2-(4-TERT-BUTYLPHENOXY) CYCLOHEXANOL
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1334.03
- Updated
- 2021/12/16
2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL Chemical Properties,Usage,Production
Uses
tBPC is a selective positive allosteric modulator for human Y4 receptor (Y4R), which enhances the activation of Y4R in G protein signaling and arrestin3 recruitment[1].
Biological Activity
tBPC is a postitive allosteric modulator of the neuropeptide Y (NPY) Y4 receptor, which is predominantly expressed in the gastrointestinal tract and activated most strongly by pancreatic polypeptide (PP). tBPC was shown to potentiate Y4R activity in G-Protein signaling and arrestin3 recruitment and to potentiate the native PP response. tBPC was selective for Y4R over other Neuropeptide Y receptors and showed no effect on the efficacy (Emax) or potency (EC50) of the NPY signal response at the Y1, Y2, or Y5 receptors at 30 μM.
References
[1] Schubert M, et al., Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator. J Med Chem. 2017 Sep 14;60(17):7605-7612. DOI:10.1021/acs.jmedchem.7b00976
2-(4-TERT-BUTYLPHENOXY)CYCLOHEXANOL Preparation Products And Raw materials
Raw materials
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