N-(3-cyanophenyl)benzamide
- Product Name
- N-(3-cyanophenyl)benzamide
- CAS No.
- 141990-91-2
- Chemical Name
- N-(3-cyanophenyl)benzamide
- Synonyms
- N-(3-Cyanophenyl);N-(3-cyanophenyl)benzamide;Benzamide, N-(3-cyanophenyl)-
- CBNumber
- CB61813942
- Molecular Formula
- C14H10N2O
- Formula Weight
- 222.24
- MOL File
- 141990-91-2.mol
N-(3-cyanophenyl)benzamide Property
- storage temp.
- Sealed in dry,Room Temperature
N-Bromosuccinimide Price
- Product number
- C955915
- Product name
- N-(3-Cyanophenyl)benzamide
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC143783
- Product name
- N-(3-Cyanophenyl)benzamide
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FC143783
- Product name
- N-(3-Cyanophenyl)benzamide
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 075386
- Product name
- N-(3-Cyanophenyl)benzamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- FC143783
- Product name
- N-(3-Cyanophenyl)benzamide
- Packaging
- 2g
- Price
- $372
- Updated
- 2021/12/16
N-(3-cyanophenyl)benzamide Chemical Properties,Usage,Production
Synthesis
93-58-3
2237-30-1
141990-91-2
GENERAL PROCEDURE: Pure m-aminobenzonitrile (1.00 mmol) and methyl benzoate (1.00 mmol) with DABAL-Me3 (202 mg, 0.8 eq.) are placed in a 5 mL microwaveable vial and dry tetrahydrofuran (1 mL) is added under argon protection. For coupled spouses containing acidic hydrogen, additional DABAL-Me3 (410 mg, 1.6 eq. total) is added. The vials were quickly capped and placed in a CEM Discover microwave reactor. Irradiation was carried out at 130 °C for 8 min at 290 W power, followed by programmed cooling (~20 min). The reaction was quenched by careful addition of 2 M hydrochloric acid (4 mL) or saturated potassium sodium tartrate solution (4 mL) (note: methane may be released). The reaction mixture is extracted with dichloromethane, dried over magnesium sulfate and concentrated to give pure N-(3-cyanophenyl)benzamide directly. For further purification, the amides lacking highly polar functional groups can be separated by column chromatography using 3:2 to 2:3 hexane:ethyl acetate as eluent; for amides containing polar functional groups such as side-chain amines, alcohols, etc., dichloromethane containing 2% v/v methanol is used as eluent.
References
[1] Tetrahedron, 2013, vol. 69, # 46, p. 9890 - 9897
N-(3-cyanophenyl)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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