4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN

Product Name: 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN
CAS No.: 172843-97-9
Chemical Name: 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN
Synonyms: Boc-ThpGly-OH;4-N-Boc-Amino-4-Carboxytetrah;4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN;4-N-BOC-Amino-4-carboxytetrahydropyrane;4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN 95%;4-N-BOC-Amino-4-carboxytetrahydropyran,95%;4-Boc-aMino-4-tetrahydropyrancarboxylic acid;4-(Boc-amino)tetrahydropyran-4-carboxylic acid;4-N-Boc-aMino-4-tetrahydropyran-carboxylic acid;4-(tert-butoxycarbonyl)-tetrahydro-2H-pyran-4-carb
CBNumber: CB6181486
Molecular Formula: C11H19NO5
Formula Weight: 245.27
MOL File: 172843-97-9.mol

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4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN Property

Melting point:: 157℃
Boiling point:: 388.23°C (rough estimate)
Density: 1.1970 (rough estimate)
refractive index: 1.4450 (estimate)
storage temp.: 2-8°C
pka: 3.76±0.20(Predicted)
form: Powder
color: White
Water Solubility: Soluble in water. (15 g/L) (25°C)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
HS Code: 29225000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B810203
Product name: 4-(Boc-amino)tetrahydropyran-4-carboxylicAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B810203
Product name: 4-(Boc-amino)tetrahydropyran-4-carboxylicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR312142
Product name: 4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylicacid
Purity: 97%
Packaging: 1g
Price: $182
Updated: 2021/12/16

Apolloscientific

Product number: OR312142
Product name: 4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylicacid
Purity: 97%
Packaging: 5g
Price: $472
Updated: 2021/12/16

Matrix Scientific

Product number: 123358
Product name: 4-(Boc-amino)tetrahydropyran-4-carboxylicacid
Purity: 95+%
Packaging: 1g
Price: $594
Updated: 2021/12/16

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4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN Chemical Properties,Usage,Production

Chemical Properties

off-white crystalline powder

Uses

Used as pharmaceutical intermediate.

Synthesis

39124-19-1

24424-99-5

172843-97-9

[Step 2] Synthesis of 4-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylic acid: to an aqueous solution (30 mL) of 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (2.2 g, 13 mmol) was added calcium hydroxide (3.0 g, 41 mmol). The reaction mixture was heated and refluxed under stirring for 48 h. The reaction mixture was subsequently filtered through diatomaceous earth and the filtrate was washed with hot water. The filtrate was concentrated under reduced pressure and the resulting crude product was dissolved in a solvent mixture of water, 1,4-dioxane and methanol (water:1,4-dioxane:methanol = 10:10:3, 23 mL). To this solution was added di-tert-butyl dicarbonate (3.4 g, 16 mmol) and sodium hydroxide (0.50 g, 13 mmol) at room temperature. The reaction mixture was stirred at room temperature for 15 hours and then concentrated under reduced pressure. Dilute hydrochloric acid (15 mL) was added to the concentrated crude product and extracted with a solvent mixture of chloroform and methanol (chloroform:methanol=10:1). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 4-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylic acid (2.6 g, 82% yield).

References

[1] Patent: EP2832724, 2015, A1. Location in patent: Paragraph 0181

4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN Preparation Products And Raw materials

Raw materials

Preparation Products

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4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN Suppliers

Belgium 1 China 85 France 1 Germany 2 India 2 United Kingdom 2 United States 12 Global 105

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View Lastest Price from 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-N-Boc-Amino-4-carboxytetrahydropyran 172843-97-9
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

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172843-97-9