(R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE
- Product Name
- (R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE
- CAS No.
- 160695-26-1
- Chemical Name
- (R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE
- Synonyms
- (R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE;R-(+)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE;(4R)-4-phenyl-3-propanoyl-oxazolidin-2-one;(R)-4-Phenyl-3-propionyloxazolidin-2-one 95+%;(4R)-4-phenyl-3-propanoyl-1,3-oxazolidin-2-one;(4R)-4-Phenyl-3-Propionyl-1,3-Oxazolidin-2-One;(R)-4-Phenyl-3-propionyl-2-oxazolidinone,99%e.e.;2-Oxazolidinone, 3-(1-oxopropyl)-4-phenyl-, (4R)-;(R)-4-Phenyl-3-propionyl-2-oxazolidinone, ee: 97%
- CBNumber
- CB6182605
- Molecular Formula
- C12H13NO3
- Formula Weight
- 219.24
- MOL File
- 160695-26-1.mol
(R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE Property
- Melting point:
- 83.5-84 °C(Solv: hexane (110-54-3); toluene (108-88-3))
- Boiling point:
- 393.1±31.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -3.13±0.40(Predicted)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8109AA
- Product name
- (R)-4-Phenyl-3-propionyloxazolidin-2-one
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- AS48516
- Product name
- (R)-4-Phenyl-3-propionyloxazolidin-2-one
- Purity
- 95+% ee
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- OR14532
- Product name
- (R)-4-Phenyl-3-propionyloxazolidin-2-one
- Purity
- 95+%
- Packaging
- 5g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- AS48516
- Product name
- (R)-4-Phenyl-3-propionyloxazolidin-2-one
- Purity
- 95+% ee
- Packaging
- 5G
- Price
- $122
- Updated
- 2021/12/16
- Product number
- 4H56-1-R6
- Product name
- (R)-4-Phenyl-3-propionyloxazolidin-2-one
- Packaging
- 5G
- Price
- $125
- Updated
- 2021/12/16
(R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE Chemical Properties,Usage,Production
Synthesis
79-03-8
90319-52-1
160695-26-1
1. (R)-4-phenyl-2-oxazolidinone (16.3 g, 1.0 eq.) was dissolved in 180 mL of dichloromethane and cooled to 0 °C in an ice bath. 2. Triethylamine (15.2 g, 1.5 eq.) and 4-dimethylaminopyridine (DMAP) (366 mg, 0.03 eq.) were added sequentially with stirring. 3. Propionyl chloride (9.2 g, 1.0 eq.) was added slowly and dropwise, keeping the reaction temperature at 0 °C and continuing to stir for 1 hour. 4. Upon completion of the reaction, the reaction mixture was diluted with methylene chloride and washed sequentially with water and saturated sodium bicarbonate solution. 5. Separate the organic phase and dry with anhydrous sodium sulfate. 6. The solvent was removed by depressurized evaporation to obtain the crude product. 7. The crude product was purified by column chromatography to afford the target compound R-4-phenyl-3-propionyl-2-oxazolidinone (III-a) (20.1 g, 92% yield).
References
[1] Organic Letters, 2011, vol. 13, # 21, p. 5762 - 5765
[2] Patent: CN105085322, 2017, B. Location in patent: Paragraph 0065; 0066; 0067; 0068
[3] Organic Process Research and Development, 2005, vol. 9, # 6, p. 827 - 829
[4] Advanced Synthesis and Catalysis, 2018, vol. 360, # 5, p. 965 - 971
(R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE manufacturers
- Product
- (R)-4-PHENYL-3-PROPIONYL-2-OXAZOLIDINONE 160695-26-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20 tons
- Release date
- 2020-11-12