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Balicatib

Product Name
Balicatib
CAS No.
354813-19-7
Chemical Name
Balicatib
Synonyms
CS-1415;AAE-581;Balicatib;Balicatib, >97%;Balicatib, >=98%;Balicatib, AAE-581;AAE581; AAE 581; AAE-581;Balicatib, 10 mM in DMSO;N-(1-(CYANOMETHYLCARBAMOYL)CYCLOHEXYL)-4-(4-PROPYLPIPERAZIN-1-YL)BENZAMIDE;Benzamide, N-[1-[[(cyanomethyl)amino]carbonyl]cyclohexyl]-4-(4-propyl-1-piperazinyl)-
CBNumber
CB61856026
Molecular Formula
C23H33N5O2
Formula Weight
411.54
MOL File
354813-19-7.mol
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Balicatib Property

Boiling point:
687.4±55.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:52.04(Max Conc. mg/mL);126.45(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);60.75(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.21(Max Conc. mM)
Ethanol:1.75(Max Conc. mg/mL);4.25(Max Conc. mM)
form 
A crystalline solid
pka
13.23±0.20(Predicted)
color 
White to off-white
InChI
InChI=1S/C23H33N5O2/c1-2-14-27-15-17-28(18-16-27)20-8-6-19(7-9-20)21(29)26-23(10-4-3-5-11-23)22(30)25-13-12-24/h6-9H,2-5,10-11,13-18H2,1H3,(H,25,30)(H,26,29)
InChIKey
LLCRBOWRJOUJAE-UHFFFAOYSA-N
SMILES
C(NC1(C(NCC#N)=O)CCCCC1)(=O)C1=CC=C(N2CCN(CCC)CC2)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17995
Product name
Balicatib
Purity
≥98%
Packaging
5mg
Price
$90
Updated
2026/04/30
Cayman Chemical
Product number
17995
Product name
Balicatib
Purity
≥98%
Packaging
10mg
Price
$168
Updated
2026/04/30
Cayman Chemical
Product number
17995
Product name
Balicatib
Purity
≥98%
Packaging
25mg
Price
$392
Updated
2026/04/30
Cayman Chemical
Product number
17995
Product name
Balicatib
Purity
≥98%
Packaging
50mg
Price
$696
Updated
2026/04/30
Cayman Chemical
Product number
17995
Product name
Balicatib
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
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Balicatib Chemical Properties,Usage,Production

Uses

Balicatib is a potent inhibitor of Cathepsin K (Cat K), a lysosomal cysteine protease, for the treatment of osteoporosis.

in vivo

Balicatib (0, 3, 10, 50 mg/kg; Oral gavage; twice daily for 18 months) partially prevented ovariectomyinduced changes in bone mass, inhibited bone turnover at most sites, and had an stimulatory effect on periosteal bone formation in cynomolgus monkeys[1].

Animal Model:11-13 years, female cynomolgus monkeys (Macaca fascicularis)[1]
Dosage:0, 3, 10, 50 mg/kg
Administration:Oral gavage; twice daily for 18 months
Result:Completely prevented ovariectomy-induced increases in BFR/BS in cancellous bone of vertebra and femur and in osteonal and endocortical bone of vertebra, significantly decreased bone formation rates.

IC 50

cathepsin K: 22 nM (IC50); cathepsin L: 48 nM (IC50); Cathepsin B: 61 nM (IC50); cathepsin S: 2900 nM (IC50)

storage

Store at -20°C

Balicatib Preparation Products And Raw materials

Raw materials

Preparation Products

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Balicatib Suppliers

China 97 France 1 India 2 The Netherlands 1 United Kingdom 1 United States 14 Global 116
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003;025-846993838003-8003 18013301593;18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
3293
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
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View Lastest Price from Balicatib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Balicatib 354813-19-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Balicatib 354813-19-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Balicatib 354813-19-7
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

354813-19-7, BalicatibRelated Search:


  • Balicatib
  • Balicatib, AAE-581
  • N-(1-(CYANOMETHYLCARBAMOYL)CYCLOHEXYL)-4-(4-PROPYLPIPERAZIN-1-YL)BENZAMIDE
  • AAE-581
  • Balicatib N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide
  • N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide Balicatib(AAE-581)
  • Balicatib, >=98%
  • AAE581; AAE 581; AAE-581
  • CS-1415
  • Balicatib, >97%
  • Benzamide, N-[1-[[(cyanomethyl)amino]carbonyl]cyclohexyl]-4-(4-propyl-1-piperazinyl)-
  • Balicatib, 10 mM in DMSO
  • 354813-19-7
  • C23H33N5O2
  • Inhibitors