ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- Product Name
- ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- CAS No.
- 144927-57-1
- Chemical Name
- ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- Synonyms
- ethyl 4-chloro-7H-pyrrolo[2;Ethyl 4-chloro-7H-pyrrolo...;3-d]pyriMidine-5-carboxylate;ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;ethyl 4-chloro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester;7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-chloro-, ethyl ester
- CBNumber
- CB61856192
- Molecular Formula
- C9H8ClN3O2
- Formula Weight
- 225.63
- MOL File
- 144927-57-1.mol
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Property
- Melting point:
- 140-141 °C
- Boiling point:
- 320.5±52.0 °C(Predicted)
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.72±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E903683
- Product name
- Ethyl4-chloro-7h-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- W3161
- Product name
- Ethyl4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 4H58-5-3K
- Product name
- Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 073191
- Product name
- Ethyl 4-chloro-7H-pyrrolo-[2,3-d]pyrimidine-5-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $574
- Updated
- 2021/12/16
- Product number
- 4H58-5-3K
- Product name
- Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $790
- Updated
- 2021/12/16
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Chemical Properties,Usage,Production
Synthesis
22276-95-5
541-41-3
144927-57-1
Under nitrogen protection, 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (2.00 g, prepared with reference to Example 8 (1)) was dissolved in tetrahydrofuran (50 mL) and cooled to -80°C. A 2.64 M butyl lithium-hexane solution (7.2 mL) was slowly added dropwise, and after completion of the dropwise addition, the reaction mixture was stirred at -80°C for 30 minutes. Subsequently, a tetrahydrofuran (5 mL) solution of ethyl chloroformate (905 μL) was added and the reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, saturated aqueous ammonium chloride solution was added to the mixture to quench the reaction and the organic phase was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent ratio of hexane/ethyl acetate (65/35 to 20/80) to afford ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate (1.43 g, 74% yield) as a colorless solid. Mass spectrum (APCI) m/z: 226/228 [M+H]+.
References
[1] Patent: EP2390254, 2011, A1. Location in patent: Page/Page column 67
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 15, p. 2883 - 2893
[3] Patent: WO2013/85802, 2013, A1. Location in patent: Page/Page column 49-50
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Suppliers
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View Lastest Price from ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate manufacturers
- Product
- Ethyl 4-chloro-7h-pyrrolo[2,3-d]pyrimidine-5-carboxylate 144927-57-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 144927-57-1
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05