A-740003

Product Name: A-740003
CAS No.: 861393-28-4
Chemical Name: A-740003
Synonyms: CS-451;A-740003;A-740003, >=99%;A 740003; A740003;A740003 - CAS 861393-28-4 - Calbiochem;P2XRs,P2X Receptor,inhibit,A-740003,A740003,Inhibitor;(E)-N-(1-((Cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyp;N-(1-(3-Cyano-2-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide;N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
CBNumber: CB61871931
Molecular Formula: C26H30N6O3
Formula Weight: 474.55
MOL File: 861393-28-4.mol

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A-740003 Property

Melting point:: 128-129 °C
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
pka: 14.09±0.46(Predicted)
form: powder
color: white to light brown

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0862
Product name: A-740003
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0862
Product name: A-740003
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $530
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.08317
Product name: A740003 - CAS 861393-28-4 - Calbiochem
Packaging: 5mg
Price: $166
Updated: 2022/05/15

Cayman Chemical

Product number: 21256
Product name: A-740003
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21256
Product name: A-740003
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

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A-740003 Chemical Properties,Usage,Production

Uses

A 740003 is a potent, selective and competitive P2X7 receptor antagonist.

General Description

A-740003 is a highly affine and selective P2X7 receptor antagonist and is best for the progression of a radiotracer for imaging of neuroinflammation by positron emission tomography.

Biological Activity

Potent, selective and competitive P2X 7 receptor antagonist (IC 50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μ M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain.

Biochem/physiol Actions

A-740003 is a selective P2X7 purinoceptor antagonist.

storage

Store at +4°C

References

[1]. prisca honore, diana donnelly-roberts, marian t. namovic, et al. a-740003 [n-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective p2x7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. journal of pharmacology and experimental therapeutics, 2006, 319:1376-1385.

A-740003 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-740003 Suppliers

China 59 United Kingdom 1 United States 16 Global 76

Shanghai Boyle Chemical Co., Ltd.

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861393-28-4, A-740003Related Search:

4-Aminoguinoline A-740003

N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide

A-740003 N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide

N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide A-740003

N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide

A-740003, >=99%

(E)-N-(1-((Cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyp

A-740003

N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide

N-[1-[(E)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide

A740003 - CAS 861393-28-4 - Calbiochem

A 740003; A740003

CS-451

Benzeneacetamide, N-[1-[[(cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxy-

N-(1-(3-Cyano-2-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide

P2XRs,P2X Receptor,inhibit,A-740003,A740003,Inhibitor

861393-28-4