Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)-
- Product Name
- Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)-
- CAS No.
- 848133-75-5
- Chemical Name
- Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)-
- Synonyms
- Neratinib Impurity 18;Neratinib Intermediate4;N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl);3-Cyano-7-ethoxy-4-hydroxy-6-(acetylaMino)quinoline;3-Cyano-7-ethoxy-4-hydroxy-6-(acetylaMino)quinolone;N-(3-cyano-7-ethoxy-4-oxo-1H-quinolin-6-yl)acetamide;N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetaMide;Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)-
- CBNumber
- CB61872190
- Molecular Formula
- C14H13N3O3
- Formula Weight
- 271.27
- MOL File
- 848133-75-5.mol
Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- Property
- Melting point:
- >250℃
- Boiling point:
- 552.1±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.84±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8271CS
- Product name
- N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
- Packaging
- 250mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- CHM0372466
- Product name
- 3-CYANO-7-ETHOXY-4-HYDROXY-6-N-ACETYLQUINOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.59
- Updated
- 2021/12/16
- Product number
- 848133755
- Product name
- N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
- Product number
- CM132455
- Product name
- N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- CD11047087
- Product name
- N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $376
- Updated
- 2021/12/16
Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- Chemical Properties,Usage,Production
Synthesis
1222172-54-4
848133-75-5
Under ice bath conditions, 60% sodium hydride (82 mg, 2.05 mmol) was slowly added to dimethyl sulfoxide (2.5 mL) and stirred for 5 min at room temperature. Subsequently, N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide (0.5 g, 1.37 mmol) was added in batches and stirring was continued for 2 h at room temperature. After confirming the complete consumption of raw materials by thin layer chromatography (TLC) monitoring, the reaction mixture was slowly poured into water (10 mL) and the pH was adjusted to 3-4 with 4 M hydrochloric acid solution.The precipitated light yellow solid was collected by filtration and dried to give N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide (0.35 g, 94.3% yield).
References
[1] Patent: US2011/263860, 2011, A1. Location in patent: Page/Page column 9-10
Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- manufacturers
- Product
- Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)- 848133-75-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-01