ChemicalBook > CAS DataBase List > Reversan

Reversan

Product Name
Reversan
CAS No.
313397-13-6
Chemical Name
Reversan
Synonyms
CBLC4H10;Reversan;N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-;5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide;ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan
CBNumber
CB61883226
Molecular Formula
C26H27N5O2
Formula Weight
441.52
MOL File
313397-13-6.mol
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Reversan Property

Melting point:
176-180°C
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: ≥8mg/mL at ~60°C
pka
11.33±0.46(Predicted)
form 
powder
color 
faint yellow to yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0173
Product name
Reversan
Purity
≥98% (HPLC)
Packaging
5mg
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0173
Product name
Reversan
Purity
≥98% (HPLC)
Packaging
25mg
Price
$519
Updated
2024/03/01
Tocris
Product number
3722
Product name
Reversan
Purity
≥99%(HPLC)
Packaging
50
Price
$952
Updated
2021/12/16
Tocris
Product number
3722
Product name
Reversan
Purity
≥99%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
Usbiological
Product number
256447
Product name
Reversan
Packaging
10mg
Price
$480
Updated
2021/12/16
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Reversan Chemical Properties,Usage,Production

Uses

Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma.

Biological Activity

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters.

storage

Store at -20°C

Reversan Preparation Products And Raw materials

Raw materials

Preparation Products

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Reversan Suppliers

China 40 India 1 The Netherlands 1 United Kingdom 1 United States 6 USA 1 Global 50
J & K SCIENTIFIC LTD.
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021-50135380
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shchemsky@sina.com
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021-65675885 18964387627
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info@efebio.com
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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313397-13-6, ReversanRelated Search:


  • N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
  • 5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide
  • Reversan
  • CBLC4H10
  • Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-
  • ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan
  • 313397-13-6
  • C26H27N5O2
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals