ChemicalBook > CAS DataBase List > (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE

(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE

Product Name
(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE
CAS No.
53872-60-9
Chemical Name
(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE
Synonyms
TRT;Travoprost Epoxide;(3aR,4R,5R,6aS)-5-Hydroxy-4-((R,E)-3-hydroxy-4-(3-(trifluoroMethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one;TCS1;EST2;TP-2;CMM9;hTRT;TV-DI;DKCA2
CBNumber
CB6196530
Molecular Formula
C18H19F3O5
Formula Weight
372.34
MOL File
53872-60-9.mol
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(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE Property

Boiling point:
520.6±50.0 °C(Predicted)
Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:10): 100 μg/ml; DMSO: 17 mg/ml; Ethanol: 20 mg/ml
form 
A crystalline solid
pka
13.34±0.20(Predicted)
biological source
rabbit
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB4502945
Product name
Anti-Telomerase antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100μG
Price
$522
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB4502944
Product name
Anti-Telomerase antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100μG
Price
$522
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB2502024
Product name
Anti-TERT antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
100μg
Price
$586
Updated
2025/07/31
Cayman Chemical
Product number
70037
Product name
Fluprostenol Lactone Diol
Purity
≥98%
Packaging
50mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
70037
Product name
Fluprostenol Lactone Diol
Purity
≥98%
Packaging
100mg
Price
$172
Updated
2024/03/01
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(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE Chemical Properties,Usage,Production

Uses

(3aR,?4R,?5R,?6aS)?-Hexahydro-?5-?hydroxy-?4-?[(1E,?3R)?-?3-?hydroxy-?4-?[3-?(trifluoromethyl)?phenoxy]?-?1-?buten-?1-?yl]?-?2H-?cyclopenta[b]?furan-?2-?one is involved in the preparation of prostaglandin derivatives.

Biological Activity

TERT (telomerase reverse transcriptase) catalyzes the de novo synthesis of telomere and results in cellular immortalization to maintain chromosomal stability. Mutations in TERT causes different types of malignancies such as gliomas, gastric cancer, and anaplastic thyroid cancer. Therefore, TERT serves as an early prognostic biomarker.

(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE Suppliers

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View Lastest Price from (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE manufacturers

Wuhan Kejiefeng Trading Co.,Ltd
Product
TRT
Price
US $0.00-0.00/bottle
Min. Order
1bottle
Purity
0.99
Supply Ability
3000bottles
Release date
2025-05-13
Henan Aochuang Chemical Co.,Ltd.
Product
(+)-(3ar,4r,5r,6as)-hexahydro-5-hydroxy-4-((1e,3r)-3-hydroxy-4-(3-trifluoromethyl)phenoxy-1-butenyl)-2h-cyclopenta(b)furan-2-one 53872-60-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Career Henan Chemical Co
Product
(+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE 53872-60-9
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

53872-60-9, (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONERelated Search:

2H-Cyclopenta[b]furan-2-one, 5-(benzoyloxy)hexahydro-4-[(1E,3S)-3-hydroxy-1-octenyl]-, (3aR,4R,5R,6aS)- [1,1'-Biphenyl]-4-carboxylic acid [3aR-[3aa,4a(E),5b,6aa]]-4-[4-(3-chlorophenoxy)-3-oxo-1-butenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester 5-(benzoyloxy)-3,3a,4,5,6,6a-hexahydro-4-(3-oxo-1-octenyl)-2H-cyclopenta(b)furan-2-one CLOPROSTENOL LACTONE DIOL 2H-Cyclopenta[b]furan-2-one, 5-(benzoyloxy)-4-[(1E,3S)-3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-1-octe nyl]hexahydro-, (3aR,4R,5R,6aS)- Fluprostenol (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE

  • Travoprost Epoxide
  • (3aR,4R,5R,6aS)-5-Hydroxy-4-((R,E)-3-hydroxy-4-(3-(trifluoroMethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
  • Fluprostenone Lactone Diol
  • Anti-TERT antibody produced in goat
  • EST2
  • TCS1
  • TRT
  • Anti-Telomerase antibody produced in rabbit
  • 2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-, (3aR,4R,5R,6aS)-
  • TV-DI
  • (3aR,4R,5R,6aS)-5-hydroxy-4-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
  • (3AR,4R,5R,6aS)-5-Hydroxy-4-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)-phenoxy)but-1-en-1-yl)hexa
  • (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE
  • (+)-FLUPROSTENOL LACTONE DIOL
  • HYDRIDE-T
  • TP-2 (TV-EDI) (Travoprost)
  • TP-2
  • TP-2 (TV-EDI)
  • ravoprost Epoxide
  • (+)-(3aR,4R,5r,6aS)-Hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-(3-trifluoromethyl)phenoxy-1-butenyl]-2H-cyclopenta[b]furan-2-one(N-3)
  • (3AR,4R,5R,6aS)-5-Hydroxy-4-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)-phenoxy)but-1-en-1-yl)hexahyd
  • Travoprost Impurity 13
  • (3aR,?4R,?5R,?6aS)?-Hexahydro-?5-?hydroxy-?4-?[(1E,?3R)?-?3-?hydroxy-?4-?[3-?(trifluoromethyl)?phenoxy]?-?1-?buten-?1-?yl]?-?2H-?cyclopenta[b]?furan-?2-?one
  • Curved prostate impurity
  • 53872-60-9 (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE
  • Prostaglandin Impurity 24
  • (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-
  • CMM9
  • DKCA2
  • DKCB4
  • hTRT
  • PFBMFT1
  • (3aR,4R,5R,6aS)-4-((R,E)-4-(3-(trifluoromethyl)phenoxy)-3-hydroxybut-1-enyl)-hexahydro-5-hydroxycyclopenta[b]furan-2-one
  • (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE
  • 53872-60-9
  • C18H19F3O5